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A Predictive Model Based on the FBXO Family Reveals the Significance of Cyclin F in Hepatocellular Carcinoma.
Gao, Dute; Li, Suxin; Guo, Huahu; Liu, Xianfu; Liu, Zhaochen; Li, Luhao; Bao, Liang; Dang, Xiaowei.
Afiliación
  • Gao D; Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Zhengzhou University, 450000 Zhengzhou, Henan, China.
  • Li S; Key Laboratory of Precision Diagnosis and Treatment in General Surgical (Hepatobiliary and Pancreatic) Diseases of Health Commission of Henan Province, 450000 Zhengzhou, Henan, China.
  • Guo H; Henan Province Engineering Research Center of Minimally Invasive Diagnosis and Treatment of Hepatobiliary and Pancreatic Diseases, 450000 Zhengzhou, Henan, China.
  • Liu X; Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Zhengzhou University, 450000 Zhengzhou, Henan, China.
  • Liu Z; Key Laboratory of Precision Diagnosis and Treatment in General Surgical (Hepatobiliary and Pancreatic) Diseases of Health Commission of Henan Province, 450000 Zhengzhou, Henan, China.
  • Li L; Henan Province Engineering Research Center of Minimally Invasive Diagnosis and Treatment of Hepatobiliary and Pancreatic Diseases, 450000 Zhengzhou, Henan, China.
  • Bao L; Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Zhengzhou University, 450000 Zhengzhou, Henan, China.
  • Dang X; Key Laboratory of Precision Diagnosis and Treatment in General Surgical (Hepatobiliary and Pancreatic) Diseases of Health Commission of Henan Province, 450000 Zhengzhou, Henan, China.
Front Biosci (Landmark Ed) ; 29(5): 202, 2024 May 24.
Article en En | MEDLINE | ID: mdl-38812312
ABSTRACT

OBJECTIVE:

The F-box protein (FBXO) family plays a key role in the malignant progression of tumors. However, the biological functions and clinical value of the FBXO family in liver cancer remain unclear. Our study comprehensively assessed the clinical value of the FBXO family in hepatocellular carcinoma (HCC) and constructed a novel signature based on the FBXO family to predict prognosis and guide precision immunotherapy.

METHODS:

The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) databases were utilized to investigate the expression characteristics and prognostic value of the FBXO family in HCC. A predictive model based on the FBXO family using TCGA database; and its predictive ability was validated using the ICGC database. Further analyses revealed that this predictive model can independently predict the overall survival (OS) rate of patients with HCC. We further analyzed the association of this predictive model with signaling pathways, clinical pathological features, somatic mutations, and immune therapy responses. Finally, we validated the biological functions of cyclin F (CCNF) through in vitro experiments.

RESULTS:

A predictive model involving three genes (CCNF, FBXO43, and FBXO45) was constructed, effectively identifying high and low-risk patients with differences in OS, clinicopathological characteristics, somatic mutations, and immune cell infiltration status. Additionally, knock-down of CCNF in HCC cell lines reduced cell proliferation in vitro, suggesting that CCNF may be a potential therapeutic target for HCC.

CONCLUSIONS:

The predictive model based on the FBXO family can effectively predict OS and the immune therapy response in HCC. Additionally, CCNF is a potential therapeutic target for HCC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma Hepatocelular / Proteínas F-Box / Neoplasias Hepáticas Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Front Biosci (Landmark Ed) Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Singapur

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma Hepatocelular / Proteínas F-Box / Neoplasias Hepáticas Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Front Biosci (Landmark Ed) Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Singapur