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Structural basis for the broad antigenicity of the computationally optimized influenza hemagglutinin X6.
Nagashima, Kaito A; Dzimianski, John V; Yang, Meng; Abendroth, Jan; Sautto, Giuseppe A; Ross, Ted M; DuBois, Rebecca M; Edwards, Thomas E; Mousa, Jarrod J.
Afiliación
  • Nagashima KA; Center for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia, Athens, GA, USA; Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.
  • Dzimianski JV; Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, CA, USA.
  • Yang M; UCB BioSciences, Bainbridge Island, WA, USA; Seattle Structural Genomics Center for Infectious Diseases (SSGCID), Seattle, WA, USA.
  • Abendroth J; UCB BioSciences, Bainbridge Island, WA, USA; Seattle Structural Genomics Center for Infectious Diseases (SSGCID), Seattle, WA, USA.
  • Sautto GA; Florida Research and Innovation Center, Cleveland Clinic, Port Saint Lucie, FL, USA.
  • Ross TM; Center for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia, Athens, GA, USA; Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, USA; Florida Research and Innovation Center, Cleveland Clinic, Port Saint Lucie, FL, USA.
  • DuBois RM; Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, CA, USA.
  • Edwards TE; UCB BioSciences, Bainbridge Island, WA, USA; Seattle Structural Genomics Center for Infectious Diseases (SSGCID), Seattle, WA, USA.
  • Mousa JJ; Center for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia, Athens, GA, USA; Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, USA; Department of Biomedical Sciences, College of Medicine, Florida State University, Tal
Structure ; 32(8): 1079-1089.e6, 2024 Aug 08.
Article en En | MEDLINE | ID: mdl-38810648
ABSTRACT
Influenza causes significant morbidity and mortality. As an alternative approach to current seasonal vaccines, the computationally optimized broadly reactive antigen (COBRA) platform has been previously applied to hemagglutinin (HA). This approach integrates wild-type HA sequences into a single immunogen to expand the breadth of accessible antibody epitopes. Adding to previous studies of H1, H3, and H5 COBRA HAs, we define the structural features of another H1 subtype COBRA, X6, that incorporates HA sequences from before and after the 2009 H1N1 influenza pandemic. We determined structures of this antigen alone and in complex with COBRA-specific as well as broadly reactive and functional antibodies, analyzing its antigenicity. We found that X6 possesses features representing both historic and recent H1 HA strains, enabling binding to both head- and stem-reactive antibodies. Overall, these data confirm the integrity of broadly reactive antibody epitopes of X6 and contribute to design efforts for a next-generation vaccine.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glicoproteínas Hemaglutininas del Virus de la Influenza / Anticuerpos Antivirales Límite: Humans Idioma: En Revista: Structure Asunto de la revista: BIOLOGIA MOLECULAR / BIOQUIMICA / BIOTECNOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glicoproteínas Hemaglutininas del Virus de la Influenza / Anticuerpos Antivirales Límite: Humans Idioma: En Revista: Structure Asunto de la revista: BIOLOGIA MOLECULAR / BIOQUIMICA / BIOTECNOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos