Your browser doesn't support javascript.
loading
Acquired Perforating Dermatosis: Clinical and Histopathological Analysis of 95 Patients From One Center.
Edek, Yusuf Can; Aypek, Yagmur; Ögüt, Betül; Erdem, Özlem; Adisen, Esra.
Afiliación
  • Edek YC; Department of Dermatology, Gazi University Faculty of Medicine, Ankara, Turkey.
  • Aypek Y; Department of Dermatology, Gazi University Faculty of Medicine, Ankara, Turkey.
  • Ögüt B; Department of Pathology, Gazi University Faculty of Medicine, Ankara, Turkey.
  • Erdem Ö; Department of Pathology, Gazi University Faculty of Medicine, Ankara, Turkey.
  • Adisen E; Department of Dermatology, Gazi University Faculty of Medicine, Ankara, Turkey.
Dermatol Pract Concept ; 14(2)2024 Apr 01.
Article en En | MEDLINE | ID: mdl-38810077
ABSTRACT

INTRODUCTION:

Acquired perforating dermatosis (APD) is a disease group characterized by transepidermal elimination of dermal connective tissue materials such as collagen, elastic fibers, and keratin through the epidermis and observed with pruritic skin lesions.

OBJECTIVES:

In this study, we aim to clarify the clinical, histopathological, and dermoscopic characteristics of APD, identify the associated systemic disease, and figure out treatment options.

METHODS:

This study was designed as a single-center retrospective, observational, cross-sectional study. We evaluated all accessible APD cases between January 2004 and June 2022 in a tertiary care hospital.

RESULTS:

A total of 95 patients with confirmed APD were included in the study. Sixty percent of the patients were women and 40% were men. The median age at diagnosis was 63.1 years (35-85 years). The most common site of lesions was the lower extremities which were detected in 86.31% of the patients. The concomitant systemic disease was identified in 84.21% of the patients. The most common systemic disease was type 2 diabetes mellitus (65.26%). Antihistamines and topical corticosteroids were the most commonly prescribed treatment agents.

CONCLUSIONS:

Transepidermal elimination of dermal connective tissue components is a feature of APD and the disease usually presents with pruritic papules and nodules with central keratotic crust or plug. The diagnosis of APD requires a clinical examination and histological investigation. APD is usually accompanied by systemic comorbidities. There are several topical and systemic medications available for APD, however, sometimes the therapy might be challenging.
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Dermatol Pract Concept Año: 2024 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Austria
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Dermatol Pract Concept Año: 2024 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Austria