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Microbiota-induced inflammatory responses in bladder tumors promote epithelial-mesenchymal transition and enhanced immune infiltration.
Li, Qiang; Sun, Yichao; Zhai, Kun; Geng, Bingzhi; Dong, Zhenkun; Ji, Lei; Chen, Hui; Cui, Yan.
Afiliación
  • Li Q; Department of Urology, Harbin Medical University Cancer Hospital, Harbin, People's Republic of China.
  • Sun Y; Department of Operating Room, Second Affiliated Hospital of Harbin Medical University, Harbin, People's Republic of China.
  • Zhai K; Department of Urology, Harbin Medical University Cancer Hospital, Harbin, People's Republic of China.
  • Geng B; Department of Urology, Harbin Medical University Cancer Hospital, Harbin, People's Republic of China.
  • Dong Z; Department of Urology, Harbin Medical University Cancer Hospital, Harbin, People's Republic of China.
  • Ji L; Geneis Beijing Co., Ltd., Beijing, People's Republic of China.
  • Chen H; Qingdao Geneis Institute of Big Data Mining and Precision Medicine, Qingdao, People's Republic of China.
  • Cui Y; Department of Urology, Harbin Medical University Cancer Hospital, Harbin, People's Republic of China.
Physiol Genomics ; 56(8): 544-554, 2024 Aug 01.
Article en En | MEDLINE | ID: mdl-38808774
ABSTRACT
The intratumoral microbiota can modulate the tumor immune microenvironment (TIME); however, the underlying mechanism by which intratumoral microbiota influences the TIME in urothelial carcinoma of the bladder (UCB) remains unclear. To address this, we collected samples from 402 patients with UCB, including paired host transcriptome and tumor microbiome data, from The Cancer Genome Atlas (TCGA). We found that the intratumoral microbiome profiles were significantly correlated with the expression pattern of epithelial-mesenchymal transition (EMT)-related genes. Furthermore, we detected that the genera Lachnoclostridium and Sutterella in tumors could indirectly promote the EMT program by inducing an inflammatory response. Moreover, the inflammatory response induced by these two intratumoral bacteria further enhanced intratumoral immune infiltration, affecting patient survival and response to immunotherapy. In addition, an independent immunotherapy cohort of 348 patients with bladder cancer was used to validate our results. Collectively, our study elucidates the potential mechanism by which the intratumoral microbiota influences the TIME of UCB and provides a new guiding strategy for the targeted therapy of UCB.NEW & NOTEWORTHY The intratumoral microbiota may mediate the bladder tumor inflammatory response, thereby promoting the epithelial-mesenchymal transition program and influencing tumor immune infiltration.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Vejiga Urinaria / Transición Epitelial-Mesenquimal / Microambiente Tumoral / Microbiota / Inflamación Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Physiol Genomics Asunto de la revista: BIOLOGIA MOLECULAR Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Vejiga Urinaria / Transición Epitelial-Mesenquimal / Microambiente Tumoral / Microbiota / Inflamación Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Physiol Genomics Asunto de la revista: BIOLOGIA MOLECULAR Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos