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Local Mechanical Modulation-Driven Evagination in Invaginated Epithelia.
Yin, Xu; Liang, Dong; He, Shuang-Quan; Zhang, Li-Yuan; Xu, Guang-Kui.
Afiliación
  • Yin X; Laboratory for Multiscale Mechanics and Medical Science, Department of Engineering Mechanics, SVL, School of Aerospace Engineering, Xi'an Jiaotong University, Xi'an 710049, China.
  • Liang D; Laboratory for Multiscale Mechanics and Medical Science, Department of Engineering Mechanics, SVL, School of Aerospace Engineering, Xi'an Jiaotong University, Xi'an 710049, China.
  • He SQ; Laboratory for Multiscale Mechanics and Medical Science, Department of Engineering Mechanics, SVL, School of Aerospace Engineering, Xi'an Jiaotong University, Xi'an 710049, China.
  • Zhang LY; School of Mechanical Engineering, University of Science and Technology Beijing, Beijing 100083, China.
  • Xu GK; Laboratory for Multiscale Mechanics and Medical Science, Department of Engineering Mechanics, SVL, School of Aerospace Engineering, Xi'an Jiaotong University, Xi'an 710049, China.
Nano Lett ; 24(23): 7069-7076, 2024 Jun 12.
Article en En | MEDLINE | ID: mdl-38808684
ABSTRACT
Local cells can actively create reverse bending (evagination) in invaginated epithelia, which plays a crucial role in the formation of elaborate organisms. However, the precise physical mechanism driving the evagination remains elusive. Here, we present a three-dimensional vertex model, incorporating the intrinsic cell polarity, to explore the complex morphogenesis induced by local mechanical modulations. We find that invaginated tissues can spontaneously generate local reverse bending due to the shift of the apicobasal polarity. Their exact shapes can be analytically determined by the local apicobasal differential tension and the internal stress. Our continuum theory exhibits three regions in a phase diagram controlled by these two parameters, showing curvature transitions from ordered to disordered states. Additionally, we delve into epithelial curvature transition induced by the nucleus repositioning, revealing its active contribution to the apicobasal force generation. The uncovered mechanical principles could potentially guide more studies on epithelial folding in diverse systems.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polaridad Celular Límite: Animals / Humans Idioma: En Revista: Nano Lett Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polaridad Celular Límite: Animals / Humans Idioma: En Revista: Nano Lett Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos