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Frailty and Exacerbation of Chronic Obstructive Pulmonary Disease: Is There Any Association?
Nishimura, Koichi; Kusunose, Masaaki; Sanda, Ryo; Shibayama, Ayumi; Nakayasu, Kazuhito.
Afiliación
  • Nishimura K; National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.
  • Kusunose M; Clinic Nishimura, Ayabe, Kyoto, Japan.
  • Sanda R; Department of Respiratory Medicine, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.
  • Shibayama A; Department of Respiratory Medicine, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.
  • Nakayasu K; Department of Nursing, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.
Int J Chron Obstruct Pulmon Dis ; 19: 1131-1139, 2024.
Article en En | MEDLINE | ID: mdl-38807967
ABSTRACT

Purpose:

This study investigated if individuals with chronic obstructive pulmonary disease (COPD) and frailty are more likely to have acute exacerbations of COPD or require hospitalization for exacerbation than those without frailty. Patients and

Methods:

Data on 135 outpatients with stable COPD were analyzed with the Cox proportional hazards model to assess the risk of future events. The Kihon Checklist was administered at baseline to classify the participants as robust, pre-frail, or frail. The follow-up period was a maximum of six and a half years.

Results:

In all, 76 patients (56.3%) experienced an exacerbation and 46 (34.1%) were hospitalized due to it. Multivariate Cox proportional hazards analysis that accounted for FEV1 and sex showed that the frail group was more likely to face future risks of COPD exacerbations [Hazard ratio 1.762 (95% CI 1.011-3.070), p=0.046] and hospitalizations for exacerbation [2.238 (1.073-4.667), p=0.032] than the robust group. No significant differences were observed when comparing robust patients to those who were pre-frail or pre-frail to frail either in exacerbations or hospitalizations. When comparing the C-indices for frailty and FEV1, the former index (exacerbation 0.591 and hospitalization 0.663) did not exceed the latter (0.663 and 0.769) in either analysis.

Conclusion:

Frail COPD patients have a more unfavorable future risk of acute exacerbations of COPD and hospitalizations for exacerbation than robust patients. However, no significant differences were observed when comparing robust patients to those who were pre-frail or pre-frail to frail, suggesting that the future risk for COPD patients with frailty is only higher compared to those who are considered robust. Additionally, FEV1 was found to be a more reliable predictor of future events than measures of frailty.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Anciano Frágil / Progresión de la Enfermedad / Enfermedad Pulmonar Obstructiva Crónica / Fragilidad / Hospitalización / Pulmón Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Chron Obstruct Pulmon Dis Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Nueva Zelanda
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Anciano Frágil / Progresión de la Enfermedad / Enfermedad Pulmonar Obstructiva Crónica / Fragilidad / Hospitalización / Pulmón Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Chron Obstruct Pulmon Dis Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Nueva Zelanda