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The protective roles of integrin α4ß7 and Amphiregulin-expressing innate lymphoid cells in lupus nephritis.
Ryu, Seungwon; Kim, Kyung Ah; Kim, Jinwoo; Lee, Dong Hun; Bae, Yong-Soo; Lee, Hajeong; Kim, Byoung Choul; Kim, Hye Young.
Afiliación
  • Ryu S; Department of Microbiology, Gachon University College of Medicine, Incheon, 21999, South Korea.
  • Kim KA; Department of Nano-Bioengineering, Incheon National University, Incheon, 22012, South Korea.
  • Kim J; Laboratory of Mucosal Immunology, Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, 03080, South Korea.
  • Lee DH; Department of Dermatology, Seoul National University College of Medicine, Seoul, 03080, South Korea.
  • Bae YS; Laboratory of Cutaneous Aging Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, 03080, South Korea.
  • Lee H; Institute of Human-Environment Interface Biology, Medical Research Center, Seoul National University, Seoul, 03080, South Korea.
  • Kim BC; Department of Biological Sciences, SRC Center for Immune Research on Non-lymphoid Organs, Sungkyunkwan University, Suwon, 16419, South Korea.
  • Kim HY; Department of Biological Sciences, Sungkyunkwan University, Suwon, 16419, South Korea.
Cell Mol Immunol ; 21(7): 723-737, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38806623
ABSTRACT
Type 2 innate lymphoid cells (ILC2s) have emerged as key regulators of the immune response in renal inflammatory diseases such as lupus nephritis. However, the mechanisms underlying ILC2 adhesion and migration in the kidney remain poorly understood. Here, we revealed the critical role of integrin α4ß7 in mediating renal ILC2 adhesion and function. We found that integrin α4ß7 enables the retention of ILC2s in the kidney by binding to VCAM-1, E-cadherin, or fibronectin on structural cells. Moreover, integrin α4ß7 knockdown reduced the production of the reparative cytokine amphiregulin (Areg) by ILC2s. In lupus nephritis, TLR7/9 signaling within the kidney microenvironment downregulates integrin α4ß7 expression, leading to decreased Areg production and promoting the egress of ILC2s. Notably, IL-33 treatment upregulated integrin α4ß7 and Areg expression in ILC2s, thereby enhancing survival and reducing inflammation in lupus nephritis. Together, these findings highlight the potential of targeting ILC2 adhesion as a therapeutic strategy for autoimmune kidney diseases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nefritis Lúpica / Linfocitos / Integrina alfa4 / Cadenas beta de Integrinas / Anfirregulina Límite: Animals / Female / Humans Idioma: En Revista: Cell Mol Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nefritis Lúpica / Linfocitos / Integrina alfa4 / Cadenas beta de Integrinas / Anfirregulina Límite: Animals / Female / Humans Idioma: En Revista: Cell Mol Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: China