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SARS-CoV-2 detection in pediatric dental clinic wastewater reflects the number of local COVID-19 cases in children under 10 years old.
Kanamori, Dai; Sakai, Jun; Iijima, Takahiro; Oono, Yuka; Malla, Bikash; Haramoto, Eiji; Hayakawa, Satoshi; Komine-Aizawa, Shihoko; Maesaki, Shigefumi; Vorup-Jensen, Thomas; Kilgore, Paul Evan; Kohase, Hikaru; Hoshino, Tomonori; Seki, Mitsuko.
Afiliación
  • Kanamori D; Division of Pediatric Dentistry, Department of Human Development and Fostering, Meikai University School of Dentistry, 1-1 Keyakidai, Sakado, Saitama, 350-0283, Japan.
  • Sakai J; Department of Infectious Disease and Infection Control, Saitama Medical University, Saitama, 350-0495, Japan.
  • Iijima T; Division of Pediatric Dentistry, Department of Human Development and Fostering, Meikai University School of Dentistry, 1-1 Keyakidai, Sakado, Saitama, 350-0283, Japan.
  • Oono Y; Division of Dental Anesthesiology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, Saitama, 350-0283, Japan.
  • Malla B; Interdisciplinary Center for River Basin Environment, University of Yamanashi, Yamanashi, 400-8511, Japan.
  • Haramoto E; Interdisciplinary Center for River Basin Environment, University of Yamanashi, Yamanashi, 400-8511, Japan.
  • Hayakawa S; Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, 173-8610, Japan.
  • Komine-Aizawa S; Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, 173-8610, Japan.
  • Maesaki S; Department of Infectious Disease and Infection Control, Saitama Medical University, Saitama, 350-0495, Japan.
  • Vorup-Jensen T; Biophysical Immunology Laboratory, Department of Biomedicine, Aarhus University, 8000, Aarhus C, Denmark.
  • Kilgore PE; Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, 48201, USA.
  • Kohase H; Division of Dental Anesthesiology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, Saitama, 350-0283, Japan.
  • Hoshino T; Division of Pediatric Dentistry, Department of Human Development and Fostering, Meikai University School of Dentistry, 1-1 Keyakidai, Sakado, Saitama, 350-0283, Japan.
  • Seki M; Division of Pediatric Dentistry, Department of Human Development and Fostering, Meikai University School of Dentistry, 1-1 Keyakidai, Sakado, Saitama, 350-0283, Japan. mitsuko.seki@dent.meikai.ac.jp.
Sci Rep ; 14(1): 12187, 2024 05 28.
Article en En | MEDLINE | ID: mdl-38806581
ABSTRACT
This was the first longitudinal study to analyze dental clinic wastewater to estimate asymptomatic SARS-CoV-2 infection trends in children. We monitored wastewater over a 14-month period, spanning three major COVID-19 waves driven by the Alpha, Delta, and Omicron variants. Each Saturday, wastewater was sampled at the Pediatric Dental Clinic of the only dental hospital in Japan's Saitama Prefecture. The relationship between the weekly number of cases in Saitama Prefecture among residents aged < 10 years (exposure) and wastewater SARS-CoV-2 RNA detection (outcome) was examined. The number of cases was significantly associated with wastewater SARS-CoV-2 RNA positivity (risk ratio, 5.36; 95% confidence interval, 1.72-16.67; Fisher's exact test, p = 0.0005). A sample from Week 8 of 2022 harbored the Omicron variant. Compared to sporadic individual testing, this approach allows continuous population-level surveillance, which is less affected by healthcare seeking and test availability. Since wastewater from pediatric dental clinics originates from the oral cavities of asymptomatic children, such testing can provide important information regarding asymptomatic COVID-19 in children, complementing clinical pediatric data.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Clínicas Odontológicas / Aguas Residuales / SARS-CoV-2 / COVID-19 Límite: Child / Child, preschool / Female / Humans / Infant / Male País/Región como asunto: Asia Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Clínicas Odontológicas / Aguas Residuales / SARS-CoV-2 / COVID-19 Límite: Child / Child, preschool / Female / Humans / Infant / Male País/Región como asunto: Asia Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido