Your browser doesn't support javascript.
loading
A combination influenza mRNA vaccine candidate provided broad protection against diverse influenza virus challenge.
Tian, Yuying; Deng, Zhuoya; Chuai, Zhengran; Li, Cong; Chang, Liangzheng; Sun, Fang; Cao, Rui; Yu, Hongyu; Xiao, Ruixue; Lu, Shuai; Xu, Yan; Yang, Penghui.
Afiliación
  • Tian Y; Faculty of Hepato-Pancreato-Biliary Surgery, Institute of Hepatobiliary Surgery, The First Medical Center, Chinese PLA General Hospital, Beijing, 100853, China; School of Basic Medicine, Inner Mongolia Medical University, Hohhot, China.
  • Deng Z; Faculty of Hepato-Pancreato-Biliary Surgery, Institute of Hepatobiliary Surgery, The First Medical Center, Chinese PLA General Hospital, Beijing, 100853, China.
  • Chuai Z; The Fifth Medical Center, Chinese PLA General Hospital, Beijing, 100039, China.
  • Li C; Faculty of Hepato-Pancreato-Biliary Surgery, Institute of Hepatobiliary Surgery, The First Medical Center, Chinese PLA General Hospital, Beijing, 100853, China; School of Basic Medicine, Inner Mongolia Medical University, Hohhot, China.
  • Chang L; Faculty of Hepato-Pancreato-Biliary Surgery, Institute of Hepatobiliary Surgery, The First Medical Center, Chinese PLA General Hospital, Beijing, 100853, China.
  • Sun F; The Fifth Medical Center, Chinese PLA General Hospital, Beijing, 100039, China.
  • Cao R; Faculty of Hepato-Pancreato-Biliary Surgery, Institute of Hepatobiliary Surgery, The First Medical Center, Chinese PLA General Hospital, Beijing, 100853, China; School of Basic Medicine, Inner Mongolia Medical University, Hohhot, China.
  • Yu H; Faculty of Hepato-Pancreato-Biliary Surgery, Institute of Hepatobiliary Surgery, The First Medical Center, Chinese PLA General Hospital, Beijing, 100853, China; School of Basic Medicine, Inner Mongolia Medical University, Hohhot, China.
  • Xiao R; Faculty of Hepato-Pancreato-Biliary Surgery, Institute of Hepatobiliary Surgery, The First Medical Center, Chinese PLA General Hospital, Beijing, 100853, China; School of Basic Medicine, Inner Mongolia Medical University, Hohhot, China.
  • Lu S; Faculty of Hepato-Pancreato-Biliary Surgery, Institute of Hepatobiliary Surgery, The First Medical Center, Chinese PLA General Hospital, Beijing, 100853, China.
  • Xu Y; Faculty of Hepato-Pancreato-Biliary Surgery, Institute of Hepatobiliary Surgery, The First Medical Center, Chinese PLA General Hospital, Beijing, 100853, China.
  • Yang P; Faculty of Hepato-Pancreato-Biliary Surgery, Institute of Hepatobiliary Surgery, The First Medical Center, Chinese PLA General Hospital, Beijing, 100853, China; School of Basic Medicine, Inner Mongolia Medical University, Hohhot, China. Electronic address: ypenghuiamms@hotmail.com.
Virology ; 596: 110125, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38805804
ABSTRACT
Influenza viruses present a significant threat to global health. The production of a universal vaccine is considered essential due to the ineffectiveness of current seasonal influenza vaccines against mutant strains. mRNA technology offers new prospects in vaccinology, with various candidates for different infectious diseases currently in development and testing phases. In this study, we encapsulated a universal influenza mRNA vaccine. The vaccine encoded influenza hemagglutinin (HA), nucleoprotein (NP), and three tandem repeats of matrix protein 2 (3M2e). Twice-vaccinated mice exhibited strong humoral and cell-mediated immune responses in vivo. Notably, these immune responses led to a significant reduction in viral load of the lungs in challenged mice, and also conferred protection against future wild-type H1N1, H3N2, or H5N1 influenza virus challenges. Our findings suggest that this mRNA-universal vaccine strategy for influenza virus may be instrumental in mitigating the impact of future influenza pandemics.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunas contra la Influenza / Proteínas de la Matriz Viral / Infecciones por Orthomyxoviridae / Glicoproteínas Hemaglutininas del Virus de la Influenza / Subtipo H3N2 del Virus de la Influenza A / Vacunas de ARNm / Ratones Endogámicos BALB C / Anticuerpos Antivirales Límite: Animals / Female / Humans Idioma: En Revista: Virology Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunas contra la Influenza / Proteínas de la Matriz Viral / Infecciones por Orthomyxoviridae / Glicoproteínas Hemaglutininas del Virus de la Influenza / Subtipo H3N2 del Virus de la Influenza A / Vacunas de ARNm / Ratones Endogámicos BALB C / Anticuerpos Antivirales Límite: Animals / Female / Humans Idioma: En Revista: Virology Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos