Tubulin Complexity in Cancer and Metastasis.

Danziger, Michael; Xu, Fuhua; Noble, Helen; Yang, Peixin; Roque, Dana M

Danziger, Michael; Xu, Fuhua; Noble, Helen; Yang, Peixin; Roque, Dana M.

Afiliación

Danziger M; Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Xu F; Division of Gynecologic Oncology, Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA.
Noble H; Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Yang P; Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Roque DM; Division of Gynecologic Oncology, Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA. droque@som.umaryland.edu.

Adv Exp Med Biol ; 1452: 21-35, 2024.

Article en En | MEDLINE | ID: mdl-38805123

ABSTRACT

ABSTRACT

Tubulin plays a fundamental role in cellular function and as the subject for microtubule-active agents in the treatment of ovarian cancer. Microtubule-binding proteins (e.g., tau, MAP1/2/4, EB1, CLIP, TOG, survivin, stathmin) and posttranslational modifications (e.g., tyrosination, deglutamylation, acetylation, glycation, phosphorylation, polyamination) further diversify tubulin functionality and may permit additional opportunities to understand microtubule behavior in disease and to develop microtubule-modifying approaches to combat ovarian cancer. Tubulin-based structures that project from suspended ovarian cancer cells known as microtentacles may contribute to metastatic potential of ovarian cancer cells and could represent an exciting novel therapeutic target.

Asunto(s)

Microtúbulos; Metástasis de la Neoplasia; Neoplasias Ováricas; Procesamiento Proteico-Postraduccional; Tubulina (Proteína); Humanos; Tubulina (Proteína)/metabolismo; Tubulina (Proteína)/química; Femenino; Microtúbulos/metabolismo; Neoplasias Ováricas/patología; Neoplasias Ováricas/metabolismo; Neoplasias Ováricas/tratamiento farmacológico; Animales; Proteínas Asociadas a Microtúbulos/metabolismo; Proteínas Asociadas a Microtúbulos/genética; Neoplasias/metabolismo; Neoplasias/patología; Neoplasias/tratamiento farmacológico

Palabras clave

Acetylation; Detyrosination; EB1End-binding protein 1 (EB1); Microtentacle; Microtubule-associated protein; Polyglutamylation; Polyglycylation; Posttranslational modifications; Tau; Tubulin code

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Tubulina (Proteína) / Procesamiento Proteico-Postraduccional / Microtúbulos / Metástasis de la Neoplasia Límite: Animals / Female / Humans Idioma: En Revista: Adv Exp Med Biol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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