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Exploring the Interplay between Diabetes and Lp(a): Implications for Cardiovascular Risk.
Pablo, Corral; Matías, Arrupe; Lavalle Cobo, Augusto; Sergio, Gimenez; Federico, Renna Nicolás.
Afiliación
  • Pablo C; Pharmacology and Research Department, FASTA University, Mar del Plata, Argentina. drpablocorral@gmail.com.
  • Matías A; Cardiometabolic Unit Coordinator - Hospital Español, Mendoza, Argentina.
  • Lavalle Cobo A; Head of Cardiology Department, Sanatorio Otamendi, CABA, Argentina.
  • Sergio G; Cardiologist O.S.E.P, Mendoza, Argentina.
  • Federico RN; Chief of Coronary Care Unit - Hospital Español de Mendoza- School of Medicine-UNCuyo, Mendoza, Argentina.
Curr Diab Rep ; 24(7): 167-172, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38805111
ABSTRACT
PURPOSE OF REVIEW The objective of this manuscript is to review and describe the relationship between Lp(a) and diabetes, exploring both their association and synergy as cardiovascular risk factors, while also describing the current evidence regarding the potential connection between low levels of Lp(a) and the presence of diabetes. RECENT

FINDINGS:

Epidemiological studies suggest a potential relationship between low to very low levels of Lp(a) and diabetes. Lipoprotein(a), or Lp(a), is an intriguing lipoprotein of genetic origin, yet its biological function remains unknown. Elevated levels of Lp(a) are associated with an increased risk of cardiovascular atherosclerosis, and coexisting diabetes status confers an even higher risk. On the other hand, epidemiological and genetic studies have paradoxically suggested a potential relationship between low to very low levels of Lp(a) and diabetes. While new pharmacological strategies are being developed to reduce Lp(a) levels, the dual aspects of this lipoprotein's behavior need to be elucidated in the near future.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Lipoproteína(a) / Factores de Riesgo de Enfermedad Cardiaca Límite: Humans Idioma: En Revista: Curr Diab Rep Asunto de la revista: ENDOCRINOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Argentina Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Lipoproteína(a) / Factores de Riesgo de Enfermedad Cardiaca Límite: Humans Idioma: En Revista: Curr Diab Rep Asunto de la revista: ENDOCRINOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Argentina Pais de publicación: Estados Unidos