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Quantifying the Length of Stay and Economic Impact of Albuterol and Levalbuterol in Hospitalized Patients With Chronic Obstructive Pulmonary Disease: A Retrospective Cohort Study.
Liu, Xun; Zhang, Hongmei; Yang, Zaixing; Ran, Yalan; Qiu, Yao; Wang, Li; Zeng, Liang; Li, Xuan; Zhi, Canghong; Lu, Junyu.
Afiliación
  • Liu X; Department of Pulmonary and Critical Care Medicine, The People's Hospital of Yongchuan District, Chongqing, CHN.
  • Zhang H; Department of Pulmonary and Critical Care Medicine, The Fifth People's Hospital of Chongqing, Chongqing, CHN.
  • Yang Z; Department of Pulmonary and Critical Care Medicine, The People's Hospital of Yongchuan District, Chongqing, CHN.
  • Ran Y; Department of Pulmonary and Critical Care Medicine, The People's Hospital of Yongchuan District, Chongqing, CHN.
  • Qiu Y; Department of Pulmonary and Critical Care Medicine, The People's Hospital of Yongchuan District, Chongqing, CHN.
  • Wang L; Department of Pulmonary and Critical Care Medicine, The People's Hospital of Yongchuan District, Chongqing, CHN.
  • Zeng L; Department of Statistics, NanPeng Artificial Intelligence Research Institute, Chongqing, CHN.
  • Li X; Department of Medicine, Joincare Pharmaceutical Group Industry Co. Ltd., Shenzhen, CHN.
  • Zhi C; Department of Medicine, Joincare Pharmaceutical Group Industry Co. Ltd., Shenzhen, CHN.
  • Lu J; Department of Pulmonary and Critical Care Medicine, The Fifth People's Hospital of Chongqing, Chongqing, CHN.
Cureus ; 16(4): e59039, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38803713
ABSTRACT
Introduction Chronic obstructive pulmonary disease (COPD) affects millions in China and imposes a considerable economic burden on hospitalized patients who experience exacerbations. Nebulized short-acting beta-2 agonists (SABA) are recommended as initial therapy for exacerbation patients, but the optimal SABA remains uncertain. This study aimed to evaluate the impact of different SABAs, such as albuterol and levalbuterol, on the length of stay (LOS) and direct medical costs among hospitalized patients diagnosed with COPD. Methods This retrospective cohort study uses linked hospital administrative data from three hospitals in Chongqing. Patients with COPD, aged 40 years and older, who had been continuously treated with nebulized albuterol or levalbuterol during hospitalization, were eligible for the study. Patients were matched 11 by sex, age, and severity according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) grades 1-4. Patients were grouped according to the different SABA treatments they received. Demographic, economic, and clinical data were retrieved. LOS and direct healthcare costs were assessed. Results A total of 158 COPD patients were included, with 79 in each treatment group. Patients treated with levalbuterol had a significantly shorter median LOS (7.0 days vs. 8.0 days, P=0.003) and fewer direct healthcare median costs (total cost ¥8,868.3 vs. ¥10,290.7, P=0.014; COPD-related western medicine fees ¥383.8 vs. ¥505.3). Patients aged 60 or older were more likely to experience longer LOS and higher direct costs. Conclusion This retrospective cohort analysis supports that albuterol was associated with longer LOS and higher costs than levalbuterol.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cureus Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cureus Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos