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The role of tryptophan and its derivatives in musculoskeletal pains: A systematic review and meta-analysis.
De La Torre Canales, Giancarlo; Al-Moraissi, Essam Ahmed; Fatih, Tina; Razavian, Artin; Westman, Julia; Yanes, Yanal; Grigoriadis, Anastasios; Christidis, Maria; Christidis, Nikolaos; Barjandi, Golnaz.
Afiliación
  • De La Torre Canales G; Division of Oral Rehabilitation, Department of Dental Medicine, Karolinska Institutet, and Scandinavian Center for Orofacial Neurosciences, Huddinge, Sweden.
  • Al-Moraissi EA; Egas Moniz Center for Interdisciplinary Research (CiiEM), Egas Moniz School of Health & Science, Caparica, Almada, Portugal.
  • Fatih T; Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Thamar University, Thamar, Yemen.
  • Razavian A; Division of Oral Rehabilitation, Department of Dental Medicine, Karolinska Institutet, and Scandinavian Center for Orofacial Neurosciences, Huddinge, Sweden.
  • Westman J; Division of Oral Rehabilitation, Department of Dental Medicine, Karolinska Institutet, and Scandinavian Center for Orofacial Neurosciences, Huddinge, Sweden.
  • Yanes Y; Division of Oral Rehabilitation, Department of Dental Medicine, Karolinska Institutet, and Scandinavian Center for Orofacial Neurosciences, Huddinge, Sweden.
  • Grigoriadis A; Division of Oral Rehabilitation, Department of Dental Medicine, Karolinska Institutet, and Scandinavian Center for Orofacial Neurosciences, Huddinge, Sweden.
  • Christidis M; Division of Oral Rehabilitation, Department of Dental Medicine, Karolinska Institutet, and Scandinavian Center for Orofacial Neurosciences, Huddinge, Sweden.
  • Christidis N; The Swedish Red Cross University, The Institute of Health Sciences, Huddinge, Sweden.
  • Barjandi G; Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden.
J Oral Rehabil ; 51(9): 1898-1910, 2024 Sep.
Article en En | MEDLINE | ID: mdl-38803211
ABSTRACT

BACKGROUND:

Studies present ambiguous findings regarding the role of tryptophan and its metabolites, kynurenine and serotonin in chronic musculoskeletal pain. This systematic review aimed to investigate the expression of tryptophan and its metabolites, serotonin and kynurenine in patients with local and generalized chronic musculoskeletal pain in comparison with pain-free controls.

METHODS:

An electronic search was conducted in the databases MEDLINE, CINAHL, EMBASE, the Cochrane Central Registry of Controlled Trials (CENTRAL) and Web of Science for clinical and observational trials from the beginning of each database to 21 April 2023. Out of 6734 articles, a total of 17 studies were included; 12 studies were used in the meta-analysis of serotonin, 3 regarding tryptophan and 2 studies for a narrative synthesis regarding kynurenine. Risk of bias was assessed using the quality assessment tool for observational cohort and cross-sectional studies of the National Heart, Lung, and Blood Institute, while the certainty of evidence was by GRADE.

RESULTS:

All included studies showed a low risk of bias. The meta-analysis showed lower blood levels of tryptophan (p < .001; very low quality of evidence) and higher blood levels of serotonin (p < .001; very low-quality evidence) in patients with generalized musculoskeletal pain, when compared to pain-free individuals. In local chronic musculoskeletal pain, there were higher blood levels of serotonin (p=.251; very low quality of evidence) compared to pain-free individuals. Regarding kynurenine, the studies reported both higher and lower blood levels in generalized chronic musculoskeletal pain compared to pain-free individuals.

CONCLUSIONS:

The blood levels of tryptophan and its metabolites serotonin and kynurenine seem to influence chronic musculoskeletal pain.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Triptófano / Serotonina / Dolor Musculoesquelético / Dolor Crónico / Quinurenina Límite: Humans Idioma: En Revista: J Oral Rehabil Año: 2024 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Triptófano / Serotonina / Dolor Musculoesquelético / Dolor Crónico / Quinurenina Límite: Humans Idioma: En Revista: J Oral Rehabil Año: 2024 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Reino Unido