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Correlation of the total superoxide dismutase activity between joint fluid and synovium in end-stage knee osteoarthritis.
Koike, Masato; Nojiri, Hidetoshi; Kanazawa, Hiroaki; Sawa, Mamiko; Miyagawa, Kei; Yamaguchi, Hiroto; Iwase, Yoshiyuki; Kurosawa, Hisashi; Kaneko, Kazuo; Ishijima, Muneaki.
Afiliación
  • Koike M; Department of Orthopaedic Surgery, Juntendo Tokyo Koto Geriatric Medical Center, Tokyo, Japan.
  • Nojiri H; Department of Orthopaedics, Juntendo University Faculty of Medicine, Tokyo, Japan.
  • Kanazawa H; Department of Orthopaedic Surgery, Juntendo Tokyo Koto Geriatric Medical Center, Tokyo, Japan. hnojiri@juntendo.ac.jp.
  • Sawa M; Department of Orthopaedics, Juntendo University Faculty of Medicine, Tokyo, Japan. hnojiri@juntendo.ac.jp.
  • Miyagawa K; Department of Orthopaedic Surgery, Juntendo Tokyo Koto Geriatric Medical Center, Tokyo, Japan.
  • Yamaguchi H; Department of Orthopaedics, Juntendo University Faculty of Medicine, Tokyo, Japan.
  • Iwase Y; Department of Orthopaedic Surgery, Juntendo Tokyo Koto Geriatric Medical Center, Tokyo, Japan.
  • Kurosawa H; Department of Orthopaedics, Juntendo University Faculty of Medicine, Tokyo, Japan.
  • Kaneko K; Department of Orthopaedic Surgery, Juntendo Tokyo Koto Geriatric Medical Center, Tokyo, Japan.
  • Ishijima M; Department of Orthopaedics, Juntendo University Faculty of Medicine, Tokyo, Japan.
Sci Rep ; 14(1): 12093, 2024 05 27.
Article en En | MEDLINE | ID: mdl-38802533
ABSTRACT
Recently, we found significantly reduced total superoxide dismutase (SOD) activity in the cartilage of patients with end-stage knee osteoarthritis (OA). In this study, we aimed to evaluate the SOD activity in serum, joint fluid, cartilage, and synovial membrane samples collected from 52 patients with end-stage knee OA who underwent total knee arthroplasty. The relationship between the total SOD activity in each tissue was evaluated using Spearman's rank correlation coefficient. The joint fluid total SOD activity was used as the objective variable, and its association with the serum, cartilage, and synovial total SOD activities was evaluated using multiple linear regression analysis. Univariate analysis revealed that joint fluid total SOD activity was positively correlated with synovial total SOD activity. Multiple linear regression analysis using joint fluid total SOD activity as the objective variable showed a positive association with synovial total SOD activity (ß = 0.493, adjusted R2 = 0.172, P < 0.01). In patients with end-stage knee OA, the state of the synovial total SOD activity is better reflected by the total SOD activity in the joint fluid than that in the cartilage. Joint fluid total SOD activity may serve as a biomarker for the treatment and prevention of synovitis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Superóxido Dismutasa / Líquido Sinovial / Membrana Sinovial / Osteoartritis de la Rodilla Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Superóxido Dismutasa / Líquido Sinovial / Membrana Sinovial / Osteoartritis de la Rodilla Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido