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Establishing Reference Intervals for Serum and Salivary Cortisol in a Selected Population in Kano, Nigeria.
Ramalan, Mansur A; Ibrahim, Zainab U; Nalado, Aisha M; Murtala, Hassan A; Abdulsalam, Kabiru; Gezawa, Ibrahim D; Musa, Baba M; Sani, Mahmoud U; Wester, C William; Salihu, Hamisu M; Aliyu, Muktar H.
Afiliación
  • Ramalan MA; Department of Medicine, Aminu Kano Teaching Hospital, Kano, Nigeria, USA.
  • Ibrahim ZU; Department of Chemical Pathology and Immunology, Faculty of Clinical Sciences, Bayero University, Kano, Nigeria, USA zeestil@yahoo.com zuibrahim.cpat@buk.edu.ng.
  • Nalado AM; Department of Medicine, Faculty of Clinical Sciences, Bayero University, Kano, Nigeria, USA.
  • Murtala HA; Kano Independent Research Centre Trust, Kano, Nigeria, USA.
  • Abdulsalam K; Department of Chemical Pathology and Immunology, Faculty of Clinical Sciences, Bayero University, Kano, Nigeria, USA.
  • Gezawa ID; Department of Medicine, Faculty of Clinical Sciences, Bayero University, Kano, Nigeria, USA.
  • Musa BM; Department of Medicine, Faculty of Clinical Sciences, Bayero University, Kano, Nigeria, USA.
  • Sani MU; Department of Medicine, Faculty of Clinical Sciences, Bayero University, Kano, Nigeria, USA.
  • Wester CW; Vanderbilt Institute for Global Health, Vanderbilt University Medical Center, USA.
  • Salihu HM; Kano Independent Research Centre Trust, Kano, Nigeria, USA.
  • Aliyu MH; Vanderbilt Institute for Global Health, Vanderbilt University Medical Center, USA.
Ann Clin Lab Sci ; 54(2): 233-238, 2024 Mar.
Article en En | MEDLINE | ID: mdl-38802150
ABSTRACT

OBJECTIVE:

Serum cortisol has long been used in the assessment of disorders of the hypothalamic-pituitary-adrenal axis. The reference interval for cortisol in both serum and saliva depends on the analytical methodology and the population studied; hence, a locally derived population-based reference interval is recommended. To our knowledge, there are no studies on reference interval determination in the study area, raising concerns about the use of reference intervals established in European and North American populations. This work aimed to establish reference intervals for baseline serum and salivary cortisol levels among healthy adults in Kano, Nigeria, using methods available in our laboratory.

METHODS:

A cross-section of 148 apparently healthy reference individuals aged 16 to 67 years were recruited from a local community in Kano, Nigeria, using a systematic sampling technique. Baseline serum cortisol was analyzed using highly sensitive and specific electrochemiluminescence quantitative measurements on an automated immunology analyzer. Salivary cortisol levels were measured using Salimetrics' competitive enzyme-linked immunosorbent assay test kits. Parametric methods with a 95% confidence interval were used to calculate reference intervals.

RESULTS:

The reference intervals for cortisol in serum and saliva were 72.0 nmo/L to 554.0 nmol/L and 0.40 nmol/L to 18.0 nmol/L, respectively. There was a weak positive correlation between serum and salivary cortisol values, but this association was not statistically significant.

CONCLUSION:

The development of locally derived adult reference intervals can improve the diagnostic utility of serum and salivary cortisol assessment and strengthen the reliability of adrenal insufficiency diagnoses in our population.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Saliva / Hidrocortisona Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Africa Idioma: En Revista: Ann Clin Lab Sci Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Saliva / Hidrocortisona Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Africa Idioma: En Revista: Ann Clin Lab Sci Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos