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Brief intervention for chronic liver disease patients with alcohol use disorder in a hepatology outpatient unit: Effects and limitations.
Hara, Nagisa; Hiraoka, Atsushi; Nakai, Masato; Shiraki, Makoto; Namisaki, Tadashi; Miyaaki, Hisamitsu; Hisanaga, Takuro; Takahashi, Hirokazu; Ohama, Hideko; Tada, Fujimasa; Sakamoto, Naoya; Nakao, Kazuhiko; Takami, Taro; Eguchi, Yuichiro; Yoshiji, Hitoshi.
Afiliación
  • Hara N; Liver Center, Saga University Hospital, Saga, Japan.
  • Hiraoka A; Department of Nutrition, Eguchi Hospital, Saga, Japan.
  • Nakai M; Gastroenterology Center, Ehime Prefectural Central Hospital, Matsuyama, Japan.
  • Shiraki M; Department of Gastroenterology and Hepatology, Hokkaido University Hospital, Sapporo, Japan.
  • Namisaki T; Department of Gastroenterology, Chuno Kosei Hospital, Gifu, Japan.
  • Miyaaki H; Department of Gastroenterology, Nara Medical University Hospital, Nara, Japan.
  • Hisanaga T; Department of Gastroenterology, Nagasaki University Hospital, Nagasaki, Japan.
  • Takahashi H; Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Ube, Japan.
  • Ohama H; Liver Center, Saga University Hospital, Saga, Japan.
  • Tada F; Gastroenterology Center, Ehime Prefectural Central Hospital, Matsuyama, Japan.
  • Sakamoto N; Gastroenterology Center, Ehime Prefectural Central Hospital, Matsuyama, Japan.
  • Nakao K; Department of Gastroenterology and Hepatology, Hokkaido University Hospital, Sapporo, Japan.
  • Takami T; Department of Gastroenterology, Nagasaki University Hospital, Nagasaki, Japan.
  • Eguchi Y; Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Ube, Japan.
  • Yoshiji H; Loco Medical General Institute, Saga, Japan.
Hepatol Res ; 2024 May 27.
Article en En | MEDLINE | ID: mdl-38801372
ABSTRACT

AIM:

It is not uncommon to encounter outpatients in the hepatology department with harmful alcohol habits. When treating such chronic liver disease (CLD) patients, an adequate intervention method for harm reduction of alcohol use, such as brief intervention (BI) or BI and nalmefene, should be considered. This study aimed to elucidate the clinical effectiveness of BI for CLD patients affected by harmful alcohol use.

METHODS:

From June 2021 to 2023, 123 Japanese CLD outpatients (hepatitis B virus  hepatitis C virus  alcoholic liver disease  others = 32184231) with an Alcohol Use Disorders Identification Test (AUDIT) score of ≥8 at the initial interview and a repeat interview with AUDIT 9 months later were enrolled. Clinical features related to patient behavior following the initial AUDIT interview were retrospectively evaluated, and compared between patients without and with BI treatment.

RESULTS:

For the non-BI and BI groups, baseline AUDIT score (median 10 [interquartile range (IQR) 9-13] vs. 12 [IQR 10-17], p = 0.016) and relative change in AUDIT score (median 0 [IQR -3 to 2] vs. -3 [IQR -7 to 0], p < 0.01) showed significant differences, whereas there was no significant difference between the groups for AUDIT score at the time of the second interview (p = 0.156). Following BI, significant improvements were observed for items 1, 2, 3, 4, 5, 8, and 10 of AUDIT (each p < 0.05).

CONCLUSION:

Patients with an alcohol use disorder as well as those with alcohol dependency who received BI showed a significant decline in AUDIT score, although the score of the follow-up AUDIT indicated continued alcohol use disorder. In addition to BI, medication with nalmefene should be considered, based on individual factors.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Hepatol Res Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Hepatol Res Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Países Bajos