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The effect of topical 0.5% humic acid gel on male rats with skin ulcer.
Samiee-Rad, Fatemeh; Ghasemi, Fatemeh; Bahadoran, Ensiyeh; Sofiabadi, Mohammad; Shalbaf, Zahra; Taherkhani, Arman; Gheibi, Nematollah.
Afiliación
  • Samiee-Rad F; Pathobiology Department, Metabolic Disease Research Center, Research Institute for Non-communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran.
  • Ghasemi F; Department of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.
  • Bahadoran E; Department of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.
  • Sofiabadi M; Physiology Department, Cellular and Molecular Research Center, Research Institute for Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran.
  • Shalbaf Z; Department of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.
  • Taherkhani A; Department of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.
  • Gheibi N; Biophysics, Biochemistry & Genetics Department, Cellular and Molecular Research Center, Research Institute for Non-communicable Diseases, Qazvin, Iran.
J Cutan Aesthet Surg ; 17(2): 131-136, 2024.
Article en En | MEDLINE | ID: mdl-38800807
ABSTRACT

Background:

Humic derivatives have antibacterial and anti-inflammatory properties.

Aim:

This study aimed to assess the experimental wound-healing effect of 0.5% humic acid gel. Materials and

Methods:

A full-thickness skin wound was created on the dorsal side of 24 Sprague Dawley male rats (220-250 g). The animals were then randomly divided into the control, sham, and experimental groups. Skin wounds were bandaged daily using sterile gauze dipped in normal saline, carboxymethylcellulose, and 0.5% humic acid for 21 days. The wound-healing rate was evaluated grossly and histologically at various time intervals post-injury.

Results:

Wound-healing percentage was significantly higher in the gel treatment group at all time points (P < 0.05). The mean number of inflammatory cells was significantly lower in the humic acid gel group than in the other groups (P < 0.001). Moreover, the number of new vascular cells and fibroblasts were significantly increased in the humic acid gel compared to the control (P < 0.001).

Conclusion:

These data confirmed that 0.5% humic acid gel accelerates wound healing, probably by anti-inflammatory effects, as well as by promoting vascular and fibroblast proliferation. Therefore, the humic acid gel may be used to improve wound care.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Cutan Aesthet Surg Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: India
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Cutan Aesthet Surg Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: India