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Pseudotargeted lipidomics analysis of scoparone on glycerophospholipid metabolism in non-alcoholic steatohepatitis mice by LC-MRM-MS.
Song, Qi; Zhao, Ziyi; Liu, Hu; Zhang, Jinling; Wang, Zhiqiang; Zhang, Yunqi; Ma, Guowei; Ge, Shaoqin.
Afiliación
  • Song Q; College of Traditional Chinese Medicine, Hebei University, Baoding, Hebei, China.
  • Zhao Z; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
  • Liu H; College of Traditional Chinese Medicine, Hebei University, Baoding, Hebei, China.
  • Zhang J; College of Traditional Chinese Medicine, Hebei University, Baoding, Hebei, China.
  • Wang Z; College of Traditional Chinese Medicine, Hebei University, Baoding, Hebei, China.
  • Zhang Y; Hebei Key Laboratory of Public Health Safety, School of Public HealthPublic Health, Hebei University, Baoding, Hebei, China.
  • Ma G; College of Traditional Chinese Medicine, Hebei University, Baoding, Hebei, China.
  • Ge S; College of Traditional Chinese Medicine, Hebei University, Baoding, Hebei, China.
PeerJ ; 12: e17380, 2024.
Article en En | MEDLINE | ID: mdl-38799063
ABSTRACT
As the inflammatory subtype of nonalcoholic fatty liver disease (NAFLD), the progression of nonalcoholic steatohepatitis (NASH) is associated with disorders of glycerophospholipid metabolism. Scoparone is the major bioactive component in Artemisia capillaris which has been widely used to treat NASH in traditional Chinese medicine. However, the underlying mechanisms of scoparone against NASH are not yet fully understood, which hinders the development of effective therapeutic agents for NASH. Given the crucial role of glycerophospholipid metabolism in NASH progression, this study aimed to characterize the differential expression of glycerophospholipids that is responsible for scoparone's pharmacological effects and assess its efficacy against NASH. Liquid chromatography-multiple reaction monitoring-mass spectrometry (LC-MRM-MS) was performed to get the concentrations of glycerophospholipids, clarify mechanisms of disease, and highlight insights into drug discovery. Additionally, pathologic findings also presented consistent changes in high-fat diet-induced NASH model, and after scoparone treatment, both the levels of glycerophospholipids and histopathology were similar to normal levels, indicating a beneficial effect during the observation time. Altogether, these results refined the insights on the mechanisms of scoparone against NASH and suggested a route to relieve NASH with glycerophospholipid metabolism. In addition, the current work demonstrated that a pseudotargeted lipidomic platform provided a novel insight into the potential mechanism of scoparone action.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glicerofosfolípidos / Cumarinas / Enfermedad del Hígado Graso no Alcohólico / Lipidómica Límite: Animals Idioma: En Revista: PeerJ Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glicerofosfolípidos / Cumarinas / Enfermedad del Hígado Graso no Alcohólico / Lipidómica Límite: Animals Idioma: En Revista: PeerJ Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos