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Impact of melatonin administration on sperm quality, steroid hormone levels, and testicular blood flow parameters in small ruminants: A meta-analysis.
Budiyanto, Agung; Hartanto, Slamet; Widayanti, Rini; Kurnianto, Heri; Wardi, Wardi; Haryanto, Bambang; Munir, Ivan Mambaul; Ibrahim, Alek; Ludfiani, Dini Dwi.
Afiliación
  • Budiyanto A; Department of Reproduction, Obstetrics, and Gynecology, Faculty of Veterinary Medicine, Gadjah Mada University, Yogyakarta, Indonesia.
  • Hartanto S; Research Center for Animal Husbandry, National Research and Innovation Agency, Bogor, Indonesia.
  • Widayanti R; Department of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Gadjah Mada University, Yogyakarta, Indonesia.
  • Kurnianto H; Research Center for Veterinary Science, National Research and Innovation Agency, Bogor, Indonesia.
  • Wardi W; Research Center for Animal Husbandry, National Research and Innovation Agency, Bogor, Indonesia.
  • Haryanto B; Research Center for Sustainable Production System and Life Cycle Assessment, National Research and Innovation Agency, Banten, Indonesia.
  • Munir IM; Research Center for Veterinary Science, National Research and Innovation Agency, Bogor, Indonesia.
  • Ibrahim A; Research Center for Animal Husbandry, National Research and Innovation Agency, Bogor, Indonesia.
  • Ludfiani DD; Research Center for Sustainable Production System and Life Cycle Assessment, National Research and Innovation Agency, Banten, Indonesia.
Vet World ; 17(4): 911-921, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38798291
ABSTRACT
Background and

Aim:

The impact of exogenous melatonin on the sperm quality of small ruminants is controversial. Therefore, this study aimed to synthesize previous findings on the influence of melatonin injection on sperm quality, steroid hormones, and testicular blood flow in small ruminants. Materials and

Methods:

Thirty studies were analyzed by computing the raw mean difference (RMD) as the effect size between the control and melatonin treatment groups, using the inverse of the variance for the random-effect model of the method of moments by DerSimonian and Laird. We assessed heterogeneity among studies using Q test. I2 statistic was used to classify the observed heterogeneity. We used Egger's regression method to indicate publication bias.

Results:

Melatonin injection (p < 0.05) affected sperm concentration (RMD = 0.42 × 109/mL), morphology (RMD = 2.82%), viability (RMD = 2.83%), acrosome integrity (RMD = 4.26%), and DNA integrity (RMD = 1.09%). Total motility (RMD = 5.62%), progressive motility (RMD = 7.90%), acrosome integrity (RMD = 8.68%), and DNA integrity (RMD = 2.01%) of post-thawed semen in the melatonin-treated group were also increased (p < 0.05). Similarly, treatment with melatonin (p < 0.05) enhanced total motility (RMD = 5.78%), progressive motility (RMD = 5.28%), curvilinear velocity (RMD = 4.09 µm/s), straight-line velocity (RMD = 5.61 µm/s), and average path velocity (RMD = 4.94 µm/s). Testosterone (RMD = 1.02 ng/mL) and estradiol 17-ß levels (RMD = 0.84 pg/mL) were elevated (p < 0.05) in the melatonin-injected group. Melatonin implantation ameliorated testicular blood flow, as indicated by a significant reduction (p < 0.05) in the resistive index (RMD = 0.11) and pulsatility index (RMD = -0.15).

Conclusion:

Melatonin administration can increase the reproductive performance of small male ruminants.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Vet World Año: 2024 Tipo del documento: Article País de afiliación: Indonesia Pais de publicación: India
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Vet World Año: 2024 Tipo del documento: Article País de afiliación: Indonesia Pais de publicación: India