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Low-Dose Radiation Therapy for Neurological Disorders: A Double-Edged Sword.
Weerasinghe-Mudiyanselage, Poornima D E; Kim, Joong-Sun; Kang, Sohi; Lee, Yun-Sil; Son, Yeonghoon; Lee, Hae-June; Moon, Changjong.
Afiliación
  • Weerasinghe-Mudiyanselage PDE; Department of Veterinary Anatomy and Animal Behavior, College of Veterinary Medicine and BK21 FOUR program, Chonnam National University, 61186 Gwangju, Republic of Korea.
  • Kim JS; Department of Veterinary Anatomy and Animal Behavior, College of Veterinary Medicine and BK21 FOUR program, Chonnam National University, 61186 Gwangju, Republic of Korea.
  • Kang S; Department of Veterinary Anatomy and Animal Behavior, College of Veterinary Medicine and BK21 FOUR program, Chonnam National University, 61186 Gwangju, Republic of Korea.
  • Lee YS; Department of Anatomy and Convergence Medical Science, Institute of Health Sciences, College of Medicine, Gyeongsang National University, 52727 Jinju, Republic of Korea.
  • Son Y; School of Pharmaceutical Sciences, Ewha Womans University, 03760 Seoul, Republic of Korea.
  • Lee HJ; Division of Radiation Biomedical Research, Korea Institute of Radiological & Medical Sciences (KIRAMS), 01812 Seoul, Republic of Korea.
  • Moon C; Division of Radiation Biomedical Research, Korea Institute of Radiological & Medical Sciences (KIRAMS), 01812 Seoul, Republic of Korea.
Discov Med ; 36(184): 898-912, 2024 May.
Article en En | MEDLINE | ID: mdl-38798250
ABSTRACT
Radiation therapy targeting the central nervous system is widely utilized for the management of various brain tumors, significantly prolonging patient survival. Presently, investigations are assessing both clinical and preclinical applications of low-dose radiation (LDR) for the treatment of neuropathological conditions beyond tumor therapy. Special focus is given to refractory neurodegenerative diseases linked to neuroinflammation, such as Alzheimer's and Parkinson's diseases, where LDR has shown promising results. This comprehensive review examines the existing experimental data regarding the utilization of LDR in neurological disorders. It covers potential advantages in reducing neurodegenerative alterations and inflammation, as well as possible adverse effects, including neurological impairments. The review underscores the importance of the exposure protocol and the age at which LDR is administered in the context of the nervous system's pathological and physiological states, as these elements are crucial in determining LDR's therapeutic and toxic outcomes. The article concludes with a discussion on the future directions and challenges in optimizing LDR use, aiming to reduce toxicity while effectively managing neurological disorders.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades del Sistema Nervioso Límite: Animals / Humans Idioma: En Revista: Discov Med Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades del Sistema Nervioso Límite: Animals / Humans Idioma: En Revista: Discov Med Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos