Your browser doesn't support javascript.
loading
Efficacy and safety of Plantago major seeds in patients with diabetic nephropathy: A randomized open-labeled controlled clinical trial.
Haider, Romella; Asghari, Majid; Aliasl, Fatemeh; Aghaali, Mohammad; Borujerdi, Razieh; Saghafi, Hossein; Moradi, Hossein.
Afiliación
  • Haider R; Department of Traditional Persian Medicine, Qom University of Medical Sciences, Qom, Iran.
  • Asghari M; Department of Traditional Persian Medicine, Qom University of Medical Sciences, Qom, Iran.
  • Aliasl F; Department of Persian Medicine, School of Traditional Medicine, Qom University of Medical Sciences, Qom, Iran.
  • Aghaali M; Department of Family and Community Medicine, School of Medicine, Qom University of Medical Sciences, Qom, Iran.
  • Borujerdi R; Department of Traditional Persian Medicine, Qom University of Medical Sciences, Qom, Iran.
  • Saghafi H; Division of Nephrology, Department of Internal Medicine, School of Medicine, Qom University of Medical Sciences, Qom, Iran. Electronic address: hsaghafi@muq.ac.ir.
  • Moradi H; Department of Traditional Persian Medicine, Qom University of Medical Sciences, Qom, Iran. Electronic address: Hmoradi@muq.ac.ir.
Explore (NY) ; 20(6): 103005, 2024 May 17.
Article en En | MEDLINE | ID: mdl-38797623
ABSTRACT

BACKGROUND:

Diabetic Nephropathy (DN) is characterized by albuminuria and a declining glomerular filtration rate (GFR) in diabetic patients. Plantago major (plantain) seed powder is traditionally used in these patients. Despite emerging and promising pre-clinical evidence, no clinical study investigated the potential efficacy of this intervention in patients with DN, which is the aim of this study.

METHODS:

In a randomized clinical trial 60 DN patients were recruited from November 2022 to March 2023 and randomly assigned to the plantain group that received standard treatment (Losartan 25 mg twice a day) and plantain seeds' powder (10 gm sachet twice a day) plus sweet almond and the control group was received only standard treatment for 60 days. Proteinuria, as per 24-hour urinary protein, as well as fasting blood sugar (FBS), blood urea nitrogen (BUN), serum creatinine, serum potassium, and quality of life score were measured at baseline and after 60 days as study outcome measures.

RESULTS:

Proteinuria was significantly decreased from 165.04 mg to 135.84 mg (p = 0.026) in the plantain group. The mean level of proteinuria was significantly lower in the plantain group (135.84 vs. 192.04, p = 0.039) compared to the control group after treatment. The plantain group showed more increase in quality of life score after treatment (33.89±9.67 vs 38.28±10.72, p = 0.041). Other outcomes showed no significant difference between the two study groups.

CONCLUSION:

Adjuvant supplementation with plantain seeds powder may decrease proteinuria in patients with diabetic nephropathy. Further studies with larger sample sizes and longer duration are needed to confirm these results.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Explore (NY) Asunto de la revista: TERAPIAS COMPLEMENTARES Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Explore (NY) Asunto de la revista: TERAPIAS COMPLEMENTARES Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Estados Unidos