Your browser doesn't support javascript.
loading
Activity of ventral hippocampal parvalbumin interneurons during anxiety.
Volitaki, Emmanouela; Forro, Thomas; Li, Kaizhen; Nevian, Thomas; Ciocchi, Stéphane.
Afiliación
  • Volitaki E; Laboratory of Systems Neuroscience, Department of Physiology, University of Bern, Bühlplatz 5, 3012 Bern, Switzerland.
  • Forro T; Laboratory of Systems Neuroscience, Department of Physiology, University of Bern, Bühlplatz 5, 3012 Bern, Switzerland.
  • Li K; Laboratory of Systems Neuroscience, Department of Physiology, University of Bern, Bühlplatz 5, 3012 Bern, Switzerland.
  • Nevian T; Neuronal Plasticity Group, Department of Physiology, University of Bern, Bühlplatz 5, 3012 Bern, Switzerland.
  • Ciocchi S; Laboratory of Systems Neuroscience, Department of Physiology, University of Bern, Bühlplatz 5, 3012 Bern, Switzerland. Electronic address: stephane.ciocchi@unibe.ch.
Cell Rep ; 43(6): 114295, 2024 Jun 25.
Article en En | MEDLINE | ID: mdl-38796850
ABSTRACT
Anxiety plays a key role in guiding behavior in response to potential threats. Anxiety is mediated by the activation of pyramidal neurons in the ventral hippocampus (vH), whose activity is controlled by GABAergic inhibitory interneurons. However, how different vH interneurons might contribute to anxiety-related processes is unclear. Here, we investigate the role of vH parvalbumin (PV)-expressing interneurons while mice transition from safe to more anxiogenic compartments of the elevated plus maze (EPM). We find that vH PV interneurons increase their activity in anxiogenic EPM compartments concomitant with dynamic changes in inhibitory interactions between PV interneurons and pyramidal neurons. By optogenetically inhibiting PV interneurons, we induce an increase in the activity of vH pyramidal neurons and persistent anxiety. Collectively, our results suggest that vH inhibitory microcircuits may act as a trigger for enduring anxiety states.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ansiedad / Parvalbúminas / Células Piramidales / Hipocampo / Interneuronas Límite: Animals Idioma: En Revista: Cell Rep Año: 2024 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ansiedad / Parvalbúminas / Células Piramidales / Hipocampo / Interneuronas Límite: Animals Idioma: En Revista: Cell Rep Año: 2024 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Estados Unidos