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[Metastatic risk factors in pheochromocytoma/paraganglioma].
Rebrova, D V; Loginova, O I; Vorobyev, S L; Vorokhobina, N V; Kozorezova, E S; Indeykin, F A; Savelyeva, T V; Sleptsov, I V; Chernikov, R A; Fedorov, E A; Semenov, A A; Chinchuk, I K; Shikhmagomedov, Sh Sh; Alekseev, M A; Krasnov, L M; Rusakov, V F.
Afiliación
  • Rebrova DV; Saint Petersburg State University, Saint Petersburg State University Hospital.
  • Loginova OI; Saint Petersburg State University, Saint Petersburg State University Hospital.
  • Vorobyev SL; National Clinical Center of Morphological Diagnostic.
  • Vorokhobina NV; North-Western State Medical University n.a. I.I. Mechnikov.
  • Kozorezova ES; National Clinical Center of Morphological Diagnostic.
  • Indeykin FA; National Clinical Center of Morphological Diagnostic.
  • Savelyeva TV; Saint Petersburg State University, Saint Petersburg State University Hospital.
  • Sleptsov IV; Saint Petersburg State University, Saint Petersburg State University Hospital.
  • Chernikov RA; Saint Petersburg State University, Saint Petersburg State University Hospital.
  • Fedorov EA; Saint Petersburg State University, Saint Petersburg State University Hospital.
  • Semenov AA; Saint Petersburg State University, Saint Petersburg State University Hospital.
  • Chinchuk IK; Saint Petersburg State University, Saint Petersburg State University Hospital.
  • Shikhmagomedov SS; Saint Petersburg State University, Saint Petersburg State University Hospital.
  • Alekseev MA; Saint Petersburg State University, Saint Petersburg State University Hospital.
  • Krasnov LM; Saint Petersburg State University, Saint Petersburg State University Hospital.
  • Rusakov VF; Saint Petersburg State University, Saint Petersburg State University Hospital.
Probl Endokrinol (Mosk) ; 70(2): 37-45, 2023 Oct 04.
Article en Ru | MEDLINE | ID: mdl-38796759
ABSTRACT
Currently, all pheochromocytoma/paraganglioma (PPGLs) are considered malignant due to metastatic potential. Consequently, PPGLs are divided into «metastatic¼ and «non-metastatic¼. Metastatic PPGLs can be with synchronous metastasis (metastases appear simultaneously with the identified primary tumor) or metachronous (metastases develop after removal of the primary tumor). The term metastatic PPGLs is not used in the presence of tumor invasion into surrounding organs and tissues, without the presence of distant metastases of lymphogenic or hematogenic origin. It is generally believed that about 10% of pheochromocytomas and about 40% of sympathetic paragangliomas have metastatic potential. On average, the prevalence of PPGLs with the presence of metastases is 15-20%. Risk factors for metastatic PPGLs are widely discussed in the literature, the most significant of which are groups of clinical, morphological and genetic characteristics. The review presents a discussion of such risk factors for metastatic PPGLs as age, localization and type of hormonal secretion of the tumor, the size and growth pattern of the adrenal lesion, the presence of necrosis and invasion into the vessels, the tumor capsule surrounding adipose tissue, high cellular and mitotic activity, Ki-67 index, expression of chromogranin B and S100 protein, the presence of genetic mutations of three main clusters (pseudohypoxia, kinase signaling and Wnt signaling).Over the past two decades, a number of authors have proposed various predictor factors and scales for assessing a probability of metastatic PPGLs. The review contains detailed description and comparison of sensitivity and specificity of such predictor scales as PASS, GAPP, M-GAPP, ASES and COPPS.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Paraganglioma / Feocromocitoma / Neoplasias de las Glándulas Suprarrenales Límite: Humans Idioma: Ru Revista: Probl Endokrinol (Mosk) Año: 2023 Tipo del documento: Article Pais de publicación: Rusia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Paraganglioma / Feocromocitoma / Neoplasias de las Glándulas Suprarrenales Límite: Humans Idioma: Ru Revista: Probl Endokrinol (Mosk) Año: 2023 Tipo del documento: Article Pais de publicación: Rusia