Your browser doesn't support javascript.
loading
Genetic profiles of oligometastatic non-small-cell lung cancer and corresponding brain metastases.
Werner, Raphael S; Rechsteiner, Markus; Moch, Holger; Curioni-Fontecedro, Alessandra; Weller, Michael; Weiss, Tobias; Regli, Luca; Le Rhun, Emilie; Mairinger, Fabian; Opitz, Isabelle; Soltermann, Alex.
Afiliación
  • Werner RS; Department of Thoracic Surgery, University Hospital Zurich, Zurich, Switzerland.
  • Rechsteiner M; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.
  • Moch H; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.
  • Curioni-Fontecedro A; Department of Medical Oncology and Hematology, University Hospital Zurich, Zurich, Switzerland.
  • Weller M; Department of Neurology and Clinical Neuroscience Center, University Hospital and University of Zurich, Zurich, Switzerland.
  • Weiss T; Department of Neurology and Clinical Neuroscience Center, University Hospital and University of Zurich, Zurich, Switzerland.
  • Regli L; Department of Neurosurgery, University Hospital Zurich, Zurich, Switzerland.
  • Le Rhun E; Department of Neurosurgery, University Hospital Zurich, Zurich, Switzerland.
  • Mairinger F; Department of Pathology, University Hospital Essen, Essen, Germany.
  • Opitz I; Department of Thoracic Surgery, University Hospital Zurich, Zurich, Switzerland.
  • Soltermann A; Pathologie Länggasse, Ittigen, Switzerland.
Eur J Cardiothorac Surg ; 65(6)2024 Jun 03.
Article en En | MEDLINE | ID: mdl-38796684
ABSTRACT

OBJECTIVES:

In patients with oligometastatic non-small-cell lung cancer (NSCLC), systemic therapy in combination with local ablative treatment of the primary tumour and all metastatic sites is associated with improved prognosis. For patient selection and treatment allocation, further knowledge about the molecular characteristics of the oligometastatic state is necessary. Here, we performed a genetic characterization of primary NSCLC and corresponding brain metastases (BM).

METHODS:

We retrospectively identified patients with oligometastatic NSCLC and synchronous (<3 months) or metachronous (>3 months) BM who underwent surgical resection of both primary tumour and BM. Mutation profiling of formalin-fixed paraffin-embedded tumour cell blocks was performed by targeted next-generation sequencing using the Oncomine Focus Assay panel.

RESULTS:

Sequencing was successful in 46 paired samples. An oncogenic alteration was present in 31 primary tumours (67.4%) and 40 BM (86.9%). The alteration of the primary tumours was preserved in the corresponding BM in 29 out of 31 cases (93.5%). The most prevalent oncogenic driver in both primary tumours and BM was a KRAS (Kirsten rat sarcoma viral oncogene) mutation (s = 21). In 16 patients (34.8%), the BM harboured additional oncogenic alterations. The presence of a private genetic alteration in the BM was an independent predictor of shorter overall survival.

CONCLUSIONS:

In oligometastatic NSCLC, BM retain the main genetic alterations of the primary tumours. Patients may profit from targeted inhibition of mutated KRAS. Additional private genetic alterations in the BM are dismal.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Carcinoma de Pulmón de Células no Pequeñas / Neoplasias Pulmonares Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Eur J Cardiothorac Surg Asunto de la revista: CARDIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Carcinoma de Pulmón de Células no Pequeñas / Neoplasias Pulmonares Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Eur J Cardiothorac Surg Asunto de la revista: CARDIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Alemania