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A novel zwitterion incorporated Nano-crystalline ceramic and polymer for bacterial resistant dental CAD-CAM block.
Kim, Min-Ji; Mangal, Utkarsh; Seo, Ji-Young; Kim, Ji-Yun; Kim, Ji-Yeong; Ryu, Jeong-Hyun; Kim, Hee-Jin; Lee, Kee-Joon; Kwon, Jae-Sung; Choi, Sung-Hwan.
Afiliación
  • Kim MJ; Division in Anatomy and Developmental Biology, Department of Oral Biology, Yonsei University College of Dentistry, 50-1 Yonsei-Ro, Seodaemun-Gu, Seoul, 03722, Republic of Korea; Department of Orthodontics, Institute of Craniofacial Deformity, Yonsei University College of Dentistry, Seoul, Republic o
  • Mangal U; BK21 FOUR Project, Yonsei University College of Dentistry, Seoul, Republic of Korea.
  • Seo JY; Department of Orthodontics, Institute of Craniofacial Deformity, Yonsei University College of Dentistry, Seoul, Republic of Korea.
  • Kim JY; Department of Orthodontics, Institute of Craniofacial Deformity, Yonsei University College of Dentistry, Seoul, Republic of Korea.
  • Kim JY; Department of Orthodontics, Institute of Craniofacial Deformity, Yonsei University College of Dentistry, Seoul, Republic of Korea.
  • Ryu JH; Department of Orthodontics, Institute of Craniofacial Deformity, Yonsei University College of Dentistry, Seoul, Republic of Korea.
  • Kim HJ; Division in Anatomy and Developmental Biology, Department of Oral Biology, Yonsei University College of Dentistry, 50-1 Yonsei-Ro, Seodaemun-Gu, Seoul, 03722, Republic of Korea; BK21 FOUR Project, Yonsei University College of Dentistry, Seoul, Republic of Korea.
  • Lee KJ; Department of Orthodontics, Institute of Craniofacial Deformity, Yonsei University College of Dentistry, Seoul, Republic of Korea.
  • Kwon JS; BK21 FOUR Project, Yonsei University College of Dentistry, Seoul, Republic of Korea; Department and Research Institute of Dental Biomaterials and Bioengineering, Yonsei University College of Dentistry, Seoul, Republic of Korea. Electronic address: jkwon@yuhs.ac.
  • Choi SH; Department of Orthodontics, Institute of Craniofacial Deformity, Yonsei University College of Dentistry, Seoul, Republic of Korea. Electronic address: selfexam@yuhs.ac.
J Dent ; 148: 105054, 2024 09.
Article en En | MEDLINE | ID: mdl-38796091
ABSTRACT

OBJECTIVES:

To create bacteria-resistant dental CAD-CAM blocks with a biofilm-resistant effect by incorporating Nano-crystalline ceramic and polymer (NCP) with 2-methacryloyloxyethyl phosphorylcholine (MPC) and sulfobetaine methacrylate (SBMA) and at an equimolar ratio, referred to as MS.

METHODS:

Experimental groups comprised NCP blocks containing zwitterions at 0.15wt% (MS015) and 0.45wt% (MS045). NCP blocks without MS served as control (CTRL). Flexural strength, surface hardness, water sorption and solubility, photometric properties, and cytotoxicity were assessed for all samples. Additionally, the resistance to single and multi-species bacterial adhesion was investigated.

RESULTS:

MS045 showed significant reduction in flexural strength (P < 0.01) compared to both CTRL and MS015. Both MS015 and MS045 showed significantly increased water sorption and significant reduction in water solubility compared to CTRL. Light transmission remained consistent across all MS content levels, but the irradiance value decreased by 12 % in the MS045 group compared to the MS015 group. Notably, compared to the CTRL group, the MS015 group exhibited enhanced resistance to adhesion by Porphyromonas gingivalis and a multi-species salivary biofilm, with biofilm thickness and biomass reduced by 45 % and 56 %, respectively.

CONCLUSIONS:

NCP containing 0.15 % MS can effectively reduce adhesion of multiple species of bacteria while maintaining physical and mechanical properties. CLINICAL

SIGNIFICANCE:

NCP integrating zwitterions is clinically advantageous in resisting bacterial adhesion at internal and external margins of milled indirect restoration.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fosforilcolina / Propiedades de Superficie / Adhesión Bacteriana / Ensayo de Materiales / Cerámica / Diseño Asistido por Computadora / Biopelículas / Resistencia Flexional / Metacrilatos Límite: Humans Idioma: En Revista: J Dent Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fosforilcolina / Propiedades de Superficie / Adhesión Bacteriana / Ensayo de Materiales / Cerámica / Diseño Asistido por Computadora / Biopelículas / Resistencia Flexional / Metacrilatos Límite: Humans Idioma: En Revista: J Dent Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido