Your browser doesn't support javascript.
loading
Neurotrophic factor levels and executive functions in children of parents with bipolar disorder: A case controlled study.
Çiçek Zekey, Özlem; Uçar, Halit Necmi; Akyürek, Fikret; Arici Sagliyan, Gökçeçiçek; Çetin, Fatih Hilmi; Türkoglu, Serhat; Altinbas, Kürsat.
Afiliación
  • Çiçek Zekey Ö; Department of Child and Adolescent Psychiatry, Sivas Numune Hospital, Sivas, Turkey. Electronic address: dr.ozlemcicek@gmail.com.
  • Uçar HN; Department of Child and Adolescent Psychiatry, Diamind Zihin Akademisi, Konya, Turkey.
  • Akyürek F; Department of Biochemistry, School of Medicine Selçuk University, Konya, Turkey.
  • Arici Sagliyan G; Department of Child and Adolescent Psychiatry, Konya City Hospital, Konya, Turkey.
  • Çetin FH; Department of Child and Adolescent Psychiatry, Diamind Zihin Akademisi, Konya, Turkey.
  • Türkoglu S; Department of Child and Adolescent Psychiatry, School of Medicine Selçuk University, Konya, Turkey.
  • Altinbas K; Department of Psychiatry, Special Clinic, Konya, Turkey.
J Affect Disord ; 359: 327-332, 2024 Aug 15.
Article en En | MEDLINE | ID: mdl-38795781
ABSTRACT

BACKGROUND:

In the current study, it was aimed to evaluate neurotrophic factor levels and their relationship with executive functions in high-risk children and adolescents (high-risk group) whose parents were diagnosed with bipolar disorder (BD) but not affected by any psychiatric disease,and in order to determine possible vulnerability factors related to the disease.

METHODS:

The study sample consisted of 32 high-risk group and 34 healthy controls. The Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version-Turkish Adaptation (KSADS-PL-T), Stroop Test, Serial Digit Learning Test (SDLT) and Cancellation Test to evaluate executive functions were administered to all participants by the clinician.Serum levels of neurotrophic factors were measured using commercial enzyme linked immunosorbent assay kits.

RESULTS:

Serum BDNF, NT-3, NT-4 levels and SDLT scores were significantly lower in the high-risk group for BD compared to the healthy control group. A moderate negative correlation was found between BDNF levels and the Cancellation Test scores in the high-risk group. In addition to these results, the odds ratios of age, NT-4, SDLT scores for being in the risky group in terms of BD diagnosis were 1.26, 0.99 and 0.86 respectively.

LIMITATIONS:

This was a cross-sectional study. Causality between study results is therefore difficult to establish. The relatively small sample size of the study is another limitation.

CONCLUSION:

The results of the present study suggest that BDNF, NT-3, NT-4 may play a role in the physiopathology of BD and may be associated with impaired executive function areas such as attention and response inhibition in the high-risk group.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Bipolar / Hijo de Padres Discapacitados / Factor Neurotrófico Derivado del Encéfalo / Neurotrofina 3 / Función Ejecutiva / Pruebas Neuropsicológicas Límite: Adolescent / Adult / Child / Female / Humans / Male Idioma: En Revista: J Affect Disord Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Bipolar / Hijo de Padres Discapacitados / Factor Neurotrófico Derivado del Encéfalo / Neurotrofina 3 / Función Ejecutiva / Pruebas Neuropsicológicas Límite: Adolescent / Adult / Child / Female / Humans / Male Idioma: En Revista: J Affect Disord Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos