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Innate Immune Evasion of PRRSV nsp11 through Degradation of the HDAC2 by Its Endoribonuclease Activity.
Zhang, He; Chen, Jianxing; Yu, Changqing; Pan, Yu; Ma, Wenjie; Feng, Hao; Xie, Jinxin; Chen, Hongyan; Wang, Yue; Xia, Changyou.
Afiliación
  • Zhang H; State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China.
  • Chen J; State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China.
  • Yu C; School of Advanced Agricultural Sciences, Yibin Vocational and Technical College, Yibin 644000, China.
  • Pan Y; State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China.
  • Ma W; State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China.
  • Feng H; State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China.
  • Xie J; College of Veterinary medicine, Xinjiang Agricultural University, Urumqi 830000, China.
  • Chen H; State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China.
  • Wang Y; State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China.
  • Xia C; State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China.
Viruses ; 16(5)2024 04 25.
Article en En | MEDLINE | ID: mdl-38793560
ABSTRACT
Porcine reproductive and respiratory syndrome virus (PRRSV), a member of the Arteriviridae family, represents a persistent menace to the global pig industry, causing reproductive failure and respiratory disease in pigs. In this study, we delved into the role of histone deacetylases (HDAC2) during PRRSV infection. Our findings revealed that HDAC2 expression is downregulated upon PRRSV infection. Notably, suppressing HDAC2 activity through specific small interfering RNA led to an increase in virus production, whereas overexpressing HDAC2 effectively inhibited PRRSV replication by boosting the expression of IFN-regulated antiviral molecules. Furthermore, we identified the virus's nonstructural protein 11 (nsp11) as a key player in reducing HDAC2 levels. Mutagenic analyses of PRRSV nsp11 revealed that its antagonistic effect on the antiviral activity of HDAC2 is dependent on its endonuclease activity. In summary, our research uncovered a novel immune evasion mechanism employed by PRRSV, providing crucial insights into the pathogenesis of this virus and guiding the development of innovative prevention strategies against PRRSV infection.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virus del Síndrome Respiratorio y Reproductivo Porcino / Síndrome Respiratorio y de la Reproducción Porcina / Endorribonucleasas / Histona Desacetilasa 2 / Evasión Inmune / Inmunidad Innata Límite: Animals / Humans Idioma: En Revista: Viruses Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virus del Síndrome Respiratorio y Reproductivo Porcino / Síndrome Respiratorio y de la Reproducción Porcina / Endorribonucleasas / Histona Desacetilasa 2 / Evasión Inmune / Inmunidad Innata Límite: Animals / Humans Idioma: En Revista: Viruses Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza