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Proposed Screening for Congenital Hyperinsulinism in Newborns: Perspective from a Neonatal-Perinatal Medicine Group.
Kaiser, Jeffrey R; Amatya, Shaili; Burke, Rebecca J; Corr, Tammy E; Darwish, Nada; Gandhi, Chintan K; Gasda, Adrienne; Glass, Kristen M; Kresch, Mitchell J; Mahdally, Sarah M; McGarvey, Maria T; Mola, Sara J; Murray, Yuanyi L; Nissly, Katie; Santiago-Aponte, Nanyaly M; Valencia, Jazmine C; Palmer, Timothy W.
Afiliación
  • Kaiser JR; Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Penn State Health Children's Hospital, Hershey, PA 17033, USA.
  • Amatya S; Department of Obstetrics and Gynecology, Penn State Milton S. Hershey Medical Center, Hershey, PA 17033, USA.
  • Burke RJ; Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Penn State Health Children's Hospital, Hershey, PA 17033, USA.
  • Corr TE; Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Penn State Health Children's Hospital, Hershey, PA 17033, USA.
  • Darwish N; Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Penn State Health Children's Hospital, Hershey, PA 17033, USA.
  • Gandhi CK; Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Penn State Health Children's Hospital, Hershey, PA 17033, USA.
  • Gasda A; Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Penn State Health Children's Hospital, Hershey, PA 17033, USA.
  • Glass KM; Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Penn State Health Children's Hospital, Hershey, PA 17033, USA.
  • Kresch MJ; Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Penn State Health Children's Hospital, Hershey, PA 17033, USA.
  • Mahdally SM; Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Penn State Health Children's Hospital, Hershey, PA 17033, USA.
  • McGarvey MT; Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Penn State Health Children's Hospital, Hershey, PA 17033, USA.
  • Mola SJ; Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Penn State Health Children's Hospital, Hershey, PA 17033, USA.
  • Murray YL; Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Penn State Health Children's Hospital, Hershey, PA 17033, USA.
  • Nissly K; Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Penn State Health Children's Hospital, Hershey, PA 17033, USA.
  • Santiago-Aponte NM; Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Penn State Health Children's Hospital, Hershey, PA 17033, USA.
  • Valencia JC; Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Penn State Health Children's Hospital, Hershey, PA 17033, USA.
  • Palmer TW; Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Penn State Health Children's Hospital, Hershey, PA 17033, USA.
J Clin Med ; 13(10)2024 May 17.
Article en En | MEDLINE | ID: mdl-38792494
ABSTRACT
This perspective work by academic neonatal providers is written specifically for the audience of newborn care providers and neonatologists involved in neonatal hypoglycemia screening. Herein, we propose adding a screen for congenital hyperinsulinism (CHI) by measuring glucose and ketone (i.e., ß-hydroxybutyrate (BOHB)) concentrations just prior to newborn hospital discharge and as close to 48 h after birth as possible, at the same time that the mandated state Newborn Dried Blood Spot Screen is obtained. In the proposed protocol, we do not recommend specific metabolite cutoffs, as our primary objective is to simply highlight the concept of screening for CHI in newborns to newborn caregivers. The premise for our proposed screen is based on the known effect of hyperinsulinism in suppressing ketogenesis, thereby limiting ketone production. We will briefly discuss genetic CHI, other forms of neonatal hypoglycemia, and their shared mechanisms; the mechanism of insulin regulation by functional pancreatic islet cell membrane KATP channels; adverse neurodevelopmental sequelae and brain injury due to missing or delaying the CHI diagnosis; the principles of a good screening test; how current neonatal hypoglycemia screening programs do not fulfill the criteria for being effective screening tests; and our proposed algorithm for screening for CHI in newborns.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Med Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Med Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza