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No Association of Polymorphisms in the Genes Encoding Interleukin-6 and Interleukin-6 Receptor Subunit Alpha with the Risk of Keloids in Polish Patients.
Dmytrzak, Andrzej; Lewandowska, Klaudyna; Boron, Agnieszka; Loniewska, Beata; Grzesch, Natalie; Brodkiewicz, Andrzej; Clark, Jeremy S C; Ciechanowicz, Andrzej; Kostrzewa-Nowak, Dorota.
Afiliación
  • Dmytrzak A; Aesthetic Med, 71-403 Szczecin, Poland.
  • Lewandowska K; Department of Clinical and Molecular Biochemistry, Pomeranian Medical University, 70-111 Szczecin, Poland.
  • Boron A; Department of Clinical and Molecular Biochemistry, Pomeranian Medical University, 70-111 Szczecin, Poland.
  • Loniewska B; Department of Neonatal Diseases, Pomeranian Medical University, 70-111 Szczecin, Poland.
  • Grzesch N; Department of Clinical and Molecular Biochemistry, Pomeranian Medical University, 70-111 Szczecin, Poland.
  • Brodkiewicz A; Department of Pediatrics, Child Nephrology, Dialysotherapy and Management of Acute Poisoning, Pomeranian Medical University, 70-780 Szczecin, Poland.
  • Clark JSC; Department of Clinical and Molecular Biochemistry, Pomeranian Medical University, 70-111 Szczecin, Poland.
  • Ciechanowicz A; Department of Clinical and Molecular Biochemistry, Pomeranian Medical University, 70-111 Szczecin, Poland.
  • Kostrzewa-Nowak D; Department of Clinical and Molecular Biochemistry, Pomeranian Medical University, 70-111 Szczecin, Poland.
Int J Mol Sci ; 25(10)2024 May 13.
Article en En | MEDLINE | ID: mdl-38791322
ABSTRACT
A keloid is a benign fibroproliferative hypertrophy of scar tissue that extends outside the original wound and invades adjacent healthy skin. Keloid formation is thought to be a complex process including overactivity of the interleukin-6 signaling pathway and genetic susceptibility. The aim of the study was to investigate possible associations between rs1800797, rs1800796, and rs1800795 polymorphisms in the promoter of the IL6 gene encoding interleukin-6 and the rs2228145 polymorphism in the IL6R gene encoding the interleukin-6 receptor subunit alpha with the predisposition to keloids in Polish patients. The genetic polymorphisms were identified either using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) or sequencing of samples of genomic DNA extracted from blood leukocytes of 86 adult patients with keloids and 100 newborns comprising a control group. No significant differences in the distributions of IL6 or IL6R alleles or genotypes were found between keloid patients and newborn controls. There were also no significant differences between both groups in the distribution of IL6 haplotypes. The IL6 rs1800797, rs1800796 and rs1800795 and IL6R rs2228145 polymorphisms were not found to predispose individuals in the study group to keloids. IL6 promoter haplotypes were not found to be associated with a higher risk of keloids in the studied group.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Interleucina-6 / Receptores de Interleucina-6 / Predisposición Genética a la Enfermedad / Polimorfismo de Nucleótido Simple / Queloide Límite: Adolescent / Adult / Female / Humans / Male / Middle aged / Newborn País/Región como asunto: Europa Idioma: En Revista: Int J Mol Sci Año: 2024 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Interleucina-6 / Receptores de Interleucina-6 / Predisposición Genética a la Enfermedad / Polimorfismo de Nucleótido Simple / Queloide Límite: Adolescent / Adult / Female / Humans / Male / Middle aged / Newborn País/Región como asunto: Europa Idioma: En Revista: Int J Mol Sci Año: 2024 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Suiza