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Enhanced Novel Object Recognition and Spatial Memory in Rats Selectively Bred for High Nicotine Preference.
Bekci, Eren; Gokmen, Ramazan Can; Kanit, Lutfiye; Gozen, Oguz; Balkan, Burcu; Koylu, Ersin O; Keser, Aysegul.
Afiliación
  • Bekci E; Neuroscience Department, Institute of Health Sciences, Ege University, Izmir 35100, Turkey.
  • Gokmen RC; Department of Physiology, School of Medicine, Ege University, Izmir 35100, Turkey.
  • Kanit L; Neuroscience Department, Institute of Health Sciences, Ege University, Izmir 35100, Turkey.
  • Gozen O; Department of Physiology, School of Medicine, Ege University, Izmir 35100, Turkey.
  • Balkan B; Neuroscience Department, Institute of Health Sciences, Ege University, Izmir 35100, Turkey.
  • Koylu EO; Department of Physiology, School of Medicine, Ege University, Izmir 35100, Turkey.
  • Keser A; Neuroscience Department, Institute of Health Sciences, Ege University, Izmir 35100, Turkey.
Brain Sci ; 14(5)2024 Apr 25.
Article en En | MEDLINE | ID: mdl-38790406
ABSTRACT
This study examined the influence of genetic background on cognitive performance in a selectively bred high nicotine-preferring (NP) rat line. Using the novel object recognition (NOR), novel location recognition (NLR), and Morris water maze (MWM) tests, we evaluated object memory, spatial memory, and spatial navigation in nicotine-naive NP rats compared to controls. Our results demonstrate that in the NOR test, both male and female NP rats spent more time exploring the novel object (higher discrimination index) compared to sex-matched controls. In the NLR, the discrimination index differed significantly from zero chance (no preference) in both NP males and females but not in controls, indicating enhanced spatial memory in the NP line. During MWM acquisition, the NP groups and control males took a shorter path to reach the platform compared to control females. On the probe trial, the distance traveled in the target quadrant was longer for NP males and females compared to their respective controls, suggesting enhanced spatial navigation and learning in the NP rats. The interesting preference for novel objects and locations displayed by NP rats may indicate a potential novelty-seeking phenotype in this line. These results highlight the complex interplay between genetic factors, cognitive function, and nicotine preference.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Brain Sci Año: 2024 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Brain Sci Año: 2024 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Suiza