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Rose geranium in sesame oil nasal spray to improve nasal vestibulitis symptoms: a randomized controlled trial.
Cathcart-Rake, Elizabeth J; Steinert, Kimberly; Smith, Deanne; Lewis-Peters, Susan; Giridhar, Karthik; Novotny, Paul; Dauer, Darcie; O'Connor, Amanda; Thomé, Stephan; Erickson, Marsha K; Friday, Bret B; Loprinzi, Charles L.
Afiliación
  • Cathcart-Rake EJ; Department of Medical Oncology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA. Cathcart-Rake.Elizabeth@mayo.edu.
  • Steinert K; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
  • Smith D; Department of Medical Oncology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.
  • Lewis-Peters S; Department of Medical Oncology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.
  • Giridhar K; Department of Medical Oncology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.
  • Novotny P; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
  • Dauer D; Essentia Health Community Cancer Research Program, 523 North Third Street, Brainerd, MN, USA.
  • O'Connor A; Department of Medical Oncology, Mayo Clinic - Mankato, Mankato, MN, USA.
  • Thomé S; Department of Medical Oncology, Mayo Clinic - Mankato, Mankato, MN, USA.
  • Erickson MK; Essentia Health Cancer Center, 420 East First St, Duluth, MN, USA.
  • Friday BB; Essentia Health Cancer Center, 420 East First St, Duluth, MN, USA.
  • Loprinzi CL; Department of Medical Oncology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.
Support Care Cancer ; 32(6): 379, 2024 May 24.
Article en En | MEDLINE | ID: mdl-38789656
ABSTRACT

PURPOSE:

The purpose of this phase III randomized double-blinded controlled trial was to investigate the efficacy of a rose geranium in sesame oil (RG) nasal spray compared with an isotonic saline (IS) nasal spray for alleviating nasal vestibulitis symptoms among patients undergoing chemotherapy.

METHODS:

Patients undergoing active chemotherapy who reported associated nasal symptoms were randomized 11 to receive RG or IS, administered twice daily for 2 weeks. Consenting participants completed nasal symptom questionnaires at baseline and then weekly while on treatment. The proportion of patients experiencing improvements in their nasal symptoms 2 weeks after initiating the nasal spray, using a six-point global impression of change score, was estimated within and between each randomized arm, and compared between arms, using Fisher's exact test. The estimated odds ratio was determined (95% confidence interval).

RESULTS:

One hundred and six patients consented to this study; 43 participants in the RG arm and 41 in the IS arm were evaluable for the primary endpoint. Participants had a mean age of 57.8 years (SD 13.9). Demographic characteristics and baseline nasal symptoms were similar between arms. Of the evaluable participants who received RG, 67.4% reported improved nasal symptoms, compared with 36.6% of the participants who received IS (P = 0.009). Adverse events were sparse and did not differ between arms.

CONCLUSION:

Rose geranium in sesame oil significantly improves nasal vestibulitis symptoms among patients undergoing chemotherapy. TRIAL REGISTRATION NCT04620369.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aceite de Sésamo / Rociadores Nasales Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Support Care Cancer Asunto de la revista: NEOPLASIAS / SERVICOS DE SAUDE Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aceite de Sésamo / Rociadores Nasales Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Support Care Cancer Asunto de la revista: NEOPLASIAS / SERVICOS DE SAUDE Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania