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Meningioma transcriptomic landscape demonstrates novel subtypes with regional associated biology and patient outcome.
Thirimanne, H Nayanga; Almiron-Bonnin, Damian; Nuechterlein, Nicholas; Arora, Sonali; Jensen, Matt; Parada, Carolina A; Qiu, Chengxiang; Szulzewsky, Frank; English, Collin W; Chen, William C; Sievers, Philipp; Nassiri, Farshad; Wang, Justin Z; Klisch, Tiemo J; Aldape, Kenneth D; Patel, Akash J; Cimino, Patrick J; Zadeh, Gelareh; Sahm, Felix; Raleigh, David R; Shendure, Jay; Ferreira, Manuel; Holland, Eric C.
Afiliación
  • Thirimanne HN; Human Biology Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
  • Almiron-Bonnin D; Department of Pathology, University of California, San Francisco, San Francisco, CA, USA.
  • Nuechterlein N; Neuropathology Unit, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
  • Arora S; Human Biology Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
  • Jensen M; Human Biology Division, Fred Hutchinson Cancer Center, Seattle, WA, USA; Seattle Translational Tumor Research Center, Fred Hutchinson Cancer Center, Seattle, WA, USA.
  • Parada CA; Department of Neurological Surgery, University of Washington Medical Center, Seattle, WA, USA.
  • Qiu C; Department of Genome Sciences, University of Washington, Seattle, WA, USA.
  • Szulzewsky F; Human Biology Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
  • English CW; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.
  • Chen WC; Departments of Radiation Oncology, Neurological Surgery, and Pathology, University of California, San Francisco, San Francisco, CA, USA.
  • Sievers P; Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Nassiri F; Department of Surgery, Division of Neurosurgery, University of Toronto, Toronto, ON, Canada.
  • Wang JZ; Department of Surgery, Division of Neurosurgery, University of Toronto, Toronto, ON, Canada.
  • Klisch TJ; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.
  • Aldape KD; Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
  • Patel AJ; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.
  • Cimino PJ; Neuropathology Unit, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
  • Zadeh G; Department of Surgery, Division of Neurosurgery, University of Toronto, Toronto, ON, Canada.
  • Sahm F; Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Raleigh DR; Departments of Radiation Oncology, Neurological Surgery, and Pathology, University of California, San Francisco, San Francisco, CA, USA.
  • Shendure J; Department of Genome Sciences, University of Washington, Seattle, WA, USA.
  • Ferreira M; Department of Neurological Surgery, University of Washington Medical Center, Seattle, WA, USA.
  • Holland EC; Human Biology Division, Fred Hutchinson Cancer Center, Seattle, WA, USA; Seattle Translational Tumor Research Center, Fred Hutchinson Cancer Center, Seattle, WA, USA. Electronic address: eholland@fredhutch.org.
Cell Genom ; 4(6): 100566, 2024 Jun 12.
Article en En | MEDLINE | ID: mdl-38788713
ABSTRACT
Meningiomas, although mostly benign, can be recurrent and fatal. World Health Organization (WHO) grading of the tumor does not always identify high-risk meningioma, and better characterizations of their aggressive biology are needed. To approach this problem, we combined 13 bulk RNA sequencing (RNA-seq) datasets to create a dimension-reduced reference landscape of 1,298 meningiomas. The clinical and genomic metadata effectively correlated with landscape regions, which led to the identification of meningioma subtypes with specific biological signatures. The time to recurrence also correlated with the map location. Further, we developed an algorithm that maps new patients onto this landscape, where the nearest neighbors predict outcome. This study highlights the utility of combining bulk transcriptomic datasets to visualize the complexity of tumor populations. Further, we provide an interactive tool for understanding the disease and predicting patient outcomes. This resource is accessible via the online tool Oncoscape, where the scientific community can explore the meningioma landscape.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transcriptoma / Neoplasias Meníngeas / Meningioma Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Cell Genom Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transcriptoma / Neoplasias Meníngeas / Meningioma Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Cell Genom Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos