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Breadth of Fc-mediated effector function correlates with clinical immunity following human malaria challenge.
Nkumama, Irene N; Ogwang, Rodney; Odera, Dennis; Musasia, Fauzia; Mwai, Kennedy; Nyamako, Lydia; Murungi, Linda; Tuju, James; Fürle, Kristin; Rosenkranz, Micha; Kimathi, Rinter; Njuguna, Patricia; Hamaluba, Mainga; Kapulu, Melissa C; Frank, Roland; Osier, Faith H A.
Afiliación
  • Nkumama IN; Centre of Infectious Diseases, Heidelberg University Hospital, Heidelberg, Germany; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute, Wellcome Trust Research Programme, Kilifi, Kenya; European Vaccine Initiative, Heidelberg, Germany.
  • Ogwang R; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute, Wellcome Trust Research Programme, Kilifi, Kenya.
  • Odera D; Centre of Infectious Diseases, Heidelberg University Hospital, Heidelberg, Germany; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute, Wellcome Trust Research Programme, Kilifi, Kenya.
  • Musasia F; Centre of Infectious Diseases, Heidelberg University Hospital, Heidelberg, Germany.
  • Mwai K; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute, Wellcome Trust Research Programme, Kilifi, Kenya; Epidemiology and Biostatistics Division, School of Public Health, University of the Witwatersrand, Johannesburg, South Africa.
  • Nyamako L; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute, Wellcome Trust Research Programme, Kilifi, Kenya.
  • Murungi L; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute, Wellcome Trust Research Programme, Kilifi, Kenya.
  • Tuju J; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute, Wellcome Trust Research Programme, Kilifi, Kenya; Department of Biotechnology and Biochemistry, Pwani University, Kilifi, Kenya.
  • Fürle K; Centre of Infectious Diseases, Heidelberg University Hospital, Heidelberg, Germany.
  • Rosenkranz M; Centre of Infectious Diseases, Heidelberg University Hospital, Heidelberg, Germany.
  • Kimathi R; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute, Wellcome Trust Research Programme, Kilifi, Kenya.
  • Njuguna P; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute, Wellcome Trust Research Programme, Kilifi, Kenya.
  • Hamaluba M; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute, Wellcome Trust Research Programme, Kilifi, Kenya.
  • Kapulu MC; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute, Wellcome Trust Research Programme, Kilifi, Kenya.
  • Frank R; Centre of Infectious Diseases, Heidelberg University Hospital, Heidelberg, Germany.
  • Osier FHA; Centre of Infectious Diseases, Heidelberg University Hospital, Heidelberg, Germany; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute, Wellcome Trust Research Programme, Kilifi, Kenya; Department of Life Sciences, Imperial College London, London, UK. Electronic addres
Immunity ; 57(6): 1215-1224.e6, 2024 Jun 11.
Article en En | MEDLINE | ID: mdl-38788711
ABSTRACT
Malaria is a life-threatening disease of global health importance, particularly in sub-Saharan Africa. The growth inhibition assay (GIA) is routinely used to evaluate, prioritize, and quantify the efficacy of malaria blood-stage vaccine candidates but does not reliably predict either naturally acquired or vaccine-induced protection. Controlled human malaria challenge studies in semi-immune volunteers provide an unparalleled opportunity to robustly identify mechanistic correlates of protection. We leveraged this platform to undertake a head-to-head comparison of seven functional antibody assays that are relevant to immunity against the erythrocytic merozoite stage of Plasmodium falciparum. Fc-mediated effector functions were strongly associated with protection from clinical symptoms of malaria and exponential parasite multiplication, while the gold standard GIA was not. The breadth of Fc-mediated effector function discriminated clinical immunity following the challenge. These findings present a shift in the understanding of the mechanisms that underpin immunity to malaria and have important implications for vaccine development.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plasmodium falciparum / Anticuerpos Antiprotozoarios / Malaria Falciparum / Vacunas contra la Malaria Límite: Adult / Female / Humans / Male Idioma: En Revista: Immunity Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plasmodium falciparum / Anticuerpos Antiprotozoarios / Malaria Falciparum / Vacunas contra la Malaria Límite: Adult / Female / Humans / Male Idioma: En Revista: Immunity Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos