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Marine Prostanoids with Cytotoxic Activity from Octocoral Clavularia spp.
Cheng, Ming-Ya; Hsu, I-Chi; Huang, Shi-Ying; Chuang, Ya-Ting; Ke, Tzi-Yi; Chang, Hsueh-Wei; Chu, Tian-Huei; Chen, Ching-Yeu; Cheng, Yuan-Bin.
Afiliación
  • Cheng MY; Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804201, Taiwan.
  • Hsu IC; Division of Pharmacy, Zuoying Armed Forces General Hospital, Kaohsiung 813204, Taiwan.
  • Huang SY; College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, China.
  • Chuang YT; PhD Program in Life Sciences, Department of Biomedical Science and Environmental Biology, College of Life Science, Kaohsiung Medical University, Kaohsiung 807378, Taiwan.
  • Ke TY; Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804201, Taiwan.
  • Chang HW; PhD Program in Life Sciences, Department of Biomedical Science and Environmental Biology, College of Life Science, Kaohsiung Medical University, Kaohsiung 807378, Taiwan.
  • Chu TH; Center for Cancer Research, Kaohsiung Medical University, Kaohsiung 807378, Taiwan.
  • Chen CY; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807378, Taiwan.
  • Cheng YB; Medical Laboratory, Medical Education and Research Center, Kaohsiung Armed Forces General Hospital, Kaohsiung 802301, Taiwan.
Mar Drugs ; 22(5)2024 May 14.
Article en En | MEDLINE | ID: mdl-38786610
ABSTRACT
Octocoral of the genus Clavularia is a kind of marine invertebrate possessing abundant cytotoxic secondary metabolites, such as prostanoids and dolabellanes. In our continuous natural product study of C. spp., two previously undescribed prostanoids [clavulone I-15-one (1) and 12-O-deacetylclavulone I (2)] and eleven known analogs (3-13) were identified. The structures of these new compounds were elucidated based on analysis of their 1D and 2D NMR, HRESIMS, and IR data. Additionally, all tested prostanoids (1 and 3-13) showed potent cytotoxic activities against the human oral cancer cell line (Ca9-22). The major compound 3 showed cytotoxic activity against the Ca9-22 cells with the IC50 value of 2.11 ± 0.03 µg/mL, which echoes the cytotoxic effect of the coral extract. In addition, in silico tools were used to predict the possible effects of isolated compounds on human tumor cell lines and nitric oxide production, as well as the pharmacological potentials.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prostaglandinas / Antozoos / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Mar Drugs Asunto de la revista: BIOLOGIA / FARMACOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prostaglandinas / Antozoos / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Mar Drugs Asunto de la revista: BIOLOGIA / FARMACOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Suiza