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Combination of a Synthetic Bioceramic Associated with a Polydioxanone-Based Membrane as an Alternative to Autogenous Bone Grafting.
Frigério, Paula Buzo; de Moura, Juliana; Pitol-Palin, Letícia; Monteiro, Naara Gabriela; Mourão, Carlos Fernando; Shibli, Jamil Awad; Okamoto, Roberta.
Afiliación
  • Frigério PB; Department of Diagnosis and Surgery, São Paulo State University (UNESP), School of Dentistry, Araçatuba 16015-050, Brazil.
  • de Moura J; Department of Diagnosis and Surgery, São Paulo State University (UNESP), School of Dentistry, Araçatuba 16015-050, Brazil.
  • Pitol-Palin L; Department of Diagnosis and Surgery, São Paulo State University (UNESP), School of Dentistry, Araçatuba 16015-050, Brazil.
  • Monteiro NG; Department of Diagnosis and Surgery, São Paulo State University (UNESP), School of Dentistry, Araçatuba 16015-050, Brazil.
  • Mourão CF; Department of Periodontology, Tufts University School of Dental Medicine, Boston, MA 02111, USA.
  • Shibli JA; Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos 07023-070, Brazil.
  • Okamoto R; Department of Basic Sciences, São Paulo State University (UNESP), School of Dentistry, Araçatuba 16066-840, Brazil.
Biomimetics (Basel) ; 9(5)2024 May 10.
Article en En | MEDLINE | ID: mdl-38786494
ABSTRACT
The purpose of this study was to evaluate the repair process in rat calvaria filled with synthetic biphasic bioceramics (Plenum® Osshp-7030, HAßTCP) or autogenous bone, covered with a polydioxanone membrane (PDO). A total of 48 rats were divided into two groups (n = 24) particulate autogenous bone + Plenum® Guide (AUTOPT+PG) or Plenum® Osshp + Plenum® Guide (PO+PG). A defect was created in the calvaria, filled with the grafts, and covered with a PDO membrane, and euthanasia took place at 7, 30, and 60 days. Micro-CT showed no statistical difference between the groups, but there was an increase in bone volume (56.26%), the number of trabeculae (2.76 mm), and intersection surface (26.76 mm2) and a decrease in total porosity (43.79%) in the PO+PG group, as well as higher values for the daily mineral apposition rate (7.16 µm/day). Histometric analysis presented material replacement and increased bone formation at 30 days compared to 7 days in both groups. Immunostaining showed a similar pattern between the groups, with an increase in proteins related to bone remodeling and formation. In conclusion, Plenum® Osshp + Plenum® Guide showed similar and sometimes superior results when compared to autogenous bone, making it a competent option as a bone substitute.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biomimetics (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biomimetics (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza