Your browser doesn't support javascript.
loading
Real-World Evidence Study of Patients with KRAS-Mutated NSCLC in Finland.
Anttalainen, Anna; Pietarinen, Paavo; Tuominen, Samuli; Mattila, Riikka; Mutka, Aino; Knuuttila, Aija.
Afiliación
  • Anttalainen A; Medaffcon Oy, 02130 Espoo, Finland.
  • Pietarinen P; Amgen AB, 02150 Espoo, Finland.
  • Tuominen S; Medaffcon Oy, 02130 Espoo, Finland.
  • Mattila R; Medaffcon Oy, 02130 Espoo, Finland.
  • Mutka A; Department of Pathology, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland.
  • Knuuttila A; Department of Pulmonary Medicine, Heart and Lung Center and Cancer Center, Helsinki University Hospital, 00290 Helsinki, Finland.
Curr Oncol ; 31(5): 2700-2712, 2024 05 11.
Article en En | MEDLINE | ID: mdl-38785486
ABSTRACT
While KRAS is the most frequently mutated oncogene in non-small cell lung cancer (NSCLC), KRAS-mutant tumors have long been considered difficult to treat and thus, an unmet need still remains. Partly due to the lack of targeted treatments, comprehensive real-world description of NSCLC patients with KRAS mutation is still largely missing in Finland. In this study, all adult patients diagnosed with locally advanced and unresectable or metastatic NSCLC from 1 January 2018 to 31 August 2020 at the Hospital District of Helsinki and Uusimaa were first identified in this retrospective registry-based real-world study. The final cohort included only patients tested with next generation sequencing (NGS) and was stratified by the KRAS mutation status. A total of 383 patients with locally advanced and unresectable or metastatic NSCLC and with NGS testing performed were identified. Patients with KRAS mutation (KRAS G12C n = 35, other KRAS n = 74) were younger than patients without KRAS mutations, were all previous or current smokers, and had more often metastatic disease at diagnosis. Also, these patients had poorer survival, with higher age, Charlson comorbidity index (CCI) being 5 or above, and KRAS G12C being the most significant risk factors associated with poorer survival. This suggests that the patients with KRAS mutation have a more aggressive disease and/or tumors with KRAS mutation are more difficult to treat, at least without effective targeted therapies.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Proto-Oncogénicas p21(ras) / Carcinoma de Pulmón de Células no Pequeñas / Neoplasias Pulmonares / Mutación Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Curr Oncol Año: 2024 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Proto-Oncogénicas p21(ras) / Carcinoma de Pulmón de Células no Pequeñas / Neoplasias Pulmonares / Mutación Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Curr Oncol Año: 2024 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Suiza