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Neutrophil-Lymphocyte, Platelet-Neutrophil, and Platelet-Lymphocyte Ratios as Indicators of Sickle Cell Anaemia Severity.
Efobi, Chilota Chibuife; Nri-Ezedi, Chisom Adaobi; Madu, Chika Sandra; Ikediashi, Chuka Charles; Ejiofor, Obiora; Ofiaeli, Chika Ifeoma.
Afiliación
  • Efobi CC; Department of Haematology, College of Health Sciences, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria.
  • Nri-Ezedi CA; Department of Paediatrics, Faculty of Medicine, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria.
  • Madu CS; Department of Anatomical Pathology, Federal Medical Center, Umuahia, Abia State, Nigeria.
  • Ikediashi CC; Department of Public Health, Glasgow Caledonian University, Glasgow, Scotland, United Kingdom.
  • Ejiofor O; Department of Paediatrics, College of Medicine, Chukwuemeka Odumegwu Ojukwu University, Awka, Anambra State, Nigeria.
  • Ofiaeli CI; Department of Family Medicine, Faculty of Medicine, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria.
Ethiop J Health Sci ; 33(5): 821-830, 2023 Sep.
Article en En | MEDLINE | ID: mdl-38784518
ABSTRACT

Background:

Sickle cell anaemia (SCA) imposes a substantial healthcare burden, affecting millions of people worldwide. Understanding the determinants influencing SCA severity is crucial for enhanced disease management and optimized patient outcomes. This study aimed to investigate the relationship between Neutrophil-Lymphocyte Ratio (NLR), Platelet-Neutrophil Ratio (PNR), Platelet-Lymphocyte Ratio (PLR), and SCA severity.

Methods:

A cohort of 45 children diagnosed with SCA and undergoing treatment at Chukwuemeka Odumegwu Ojukwu University Teaching Hospital, Awka, was included in this study. Demographic and clinical data, along with laboratory measurements of the aforementioned ratios, were collected. The severity of SCA was assessed using numerical scoring.

Results:

The analysis revealed that PNR and PLR emerged as significant predictors of SCA severity, irrespective of the level of adiposity. In contrast, NLR demonstrated no predictive value in relation to SCA severity.

Conclusion:

The findings challenge the conventional notion that neutrophils alone play a central role in the pathogenesis of sickle cell crises. These results contribute to a deeper understanding of the disease and provide insights into possible alternative mechanisms underlying SCA severity. Further research is warranted to explore the intricate interplay between platelets, neutrophils, lymphocytes, and other biological factors within the context of SCA. Ultimately, this knowledge may pave the way for targeted interventions and improved management strategies for individuals living with SCA.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Índice de Severidad de la Enfermedad / Plaquetas / Linfocitos / Anemia de Células Falciformes / Neutrófilos Límite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Ethiop J Health Sci Año: 2023 Tipo del documento: Article País de afiliación: Nigeria Pais de publicación: Etiopia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Índice de Severidad de la Enfermedad / Plaquetas / Linfocitos / Anemia de Células Falciformes / Neutrófilos Límite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Ethiop J Health Sci Año: 2023 Tipo del documento: Article País de afiliación: Nigeria Pais de publicación: Etiopia