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Base-pairing of uracil and 2,6-diaminopurine: from cocrystals to photoreactivity.
Stolar, Tomislav; Pearce, Ben K D; Etter, Martin; Truong, Khai-Nghi; Ostojic, Tea; Krajnc, Andraz; Mali, Gregor; Rossi, Barbara; Molcanov, Kresimir; Loncaric, Ivor; Mestrovic, Ernest; Uzarevic, Krunoslav; Grisanti, Luca.
Afiliación
  • Stolar T; Ruder Boskovic Institute, Bijenicka c. 54, 10000 Zagreb, Croatia.
  • Pearce BKD; Federal Institute for Materials Research and Testing (BAM), Richard-Willstätter-Straße 11, 12489 Berlin, Germany.
  • Etter M; Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA.
  • Truong KN; Deutsches Elektronen-Synchrotron (DESY), Notkestraße 85, 22607 Hamburg, Germany.
  • Ostojic T; Rigaku Europe SE, Hugenottenallee 167, 63263 Neu-Isenburg, Germany.
  • Krajnc A; Ruder Boskovic Institute, Bijenicka c. 54, 10000 Zagreb, Croatia.
  • Mali G; National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia.
  • Rossi B; National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia.
  • Molcanov K; Elettra Sincrotrone Trieste, Strada Statale 14 km 163.5, 34149 Trieste, Italy.
  • Loncaric I; Ruder Boskovic Institute, Bijenicka c. 54, 10000 Zagreb, Croatia.
  • Mestrovic E; Ruder Boskovic Institute, Bijenicka c. 54, 10000 Zagreb, Croatia.
  • Uzarevic K; Faculty of Chemical Engineering and Technology, University of Zagreb, Trg Marka Marulica 19, 10000 Zagreb, Croatia.
  • Grisanti L; Ruder Boskovic Institute, Bijenicka c. 54, 10000 Zagreb, Croatia.
iScience ; 27(6): 109894, 2024 Jun 21.
Article en En | MEDLINE | ID: mdl-38783999
ABSTRACT
We show that the non-canonical nucleobase 2,6-diaminopurine (D) spontaneously base pairs with uracil (U) in water and the solid state without the need to be attached to the ribose-phosphate backbone. Depending on the reaction conditions, D and U assemble in thermodynamically stable hydrated and anhydrated D-U base-paired cocrystals. Under UV irradiation, an aqueous solution of D-U base-pair undergoes photochemical degradation, while a pure aqueous solution of U does not. Our simulations suggest that D may trigger the U photodimerization and show that complementary base-pairing modifies the photochemical properties of nucleobases, which might have implications for prebiotic chemistry.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: IScience Año: 2024 Tipo del documento: Article País de afiliación: Croacia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: IScience Año: 2024 Tipo del documento: Article País de afiliación: Croacia Pais de publicación: Estados Unidos