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[Advances in paclitaxel biosynthesis and transcriptional regulation mechanisms].
Sun, Fanshu; Dang, Shuyang; Zheng, Dongran; Zhang, He; Wang, Yu; Li, Yuhua; Wu, Hao.
Afiliación
  • Sun F; Key Laboratory of Saline-alkali Vegetation Ecology Restoration, College of Life Sciences, Northeast Forestry University, Harbin 150040, Heilongjiang, China.
  • Dang S; Key Laboratory of Saline-alkali Vegetation Ecology Restoration, College of Life Sciences, Northeast Forestry University, Harbin 150040, Heilongjiang, China.
  • Zheng D; Key Laboratory of Saline-alkali Vegetation Ecology Restoration, College of Life Sciences, Northeast Forestry University, Harbin 150040, Heilongjiang, China.
  • Zhang H; Key Laboratory of Saline-alkali Vegetation Ecology Restoration, College of Life Sciences, Northeast Forestry University, Harbin 150040, Heilongjiang, China.
  • Wang Y; Key Laboratory of Saline-alkali Vegetation Ecology Restoration, College of Life Sciences, Northeast Forestry University, Harbin 150040, Heilongjiang, China.
  • Li Y; Key Laboratory of Saline-alkali Vegetation Ecology Restoration, College of Life Sciences, Northeast Forestry University, Harbin 150040, Heilongjiang, China.
  • Wu H; Key Laboratory of Saline-alkali Vegetation Ecology Restoration, College of Life Sciences, Northeast Forestry University, Harbin 150040, Heilongjiang, China.
Sheng Wu Gong Cheng Xue Bao ; 40(5): 1380-1405, 2024 May 25.
Article en Zh | MEDLINE | ID: mdl-38783804
ABSTRACT
Paclitaxel, a rare diterpene extracted from the bark of Chinese yew (Taxus chinensis), is renowned for its anti-cancer activity and serves as a primary drug for treating cancers. Due to the exceptionally low content of paclitaxel in the bark, a semi-synthetic method that depletes Chinese yew resources is used in the production of paclitaxel, which, however, fails to meet the escalating clinical demand. In recent years, researchers have achieved significant progress in heterologous biosynthesis and metabolic engineering for the production of paclitaxel. This article comprehensively reviews the advancements in paclitaxel production, encompassing chemical synthesis, heterologous biosynthesis, and cell engineering. It provides an in-depth introduction to the biosynthetic pathway and transcriptional regulation mechanisms of paclitaxel, aiming to provide a valuable reference for further research on paclitaxel biosynthesis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Paclitaxel Idioma: Zh Revista: Sheng Wu Gong Cheng Xue Bao Asunto de la revista: BIOTECNOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: China
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Paclitaxel Idioma: Zh Revista: Sheng Wu Gong Cheng Xue Bao Asunto de la revista: BIOTECNOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: China