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Heart disease in pregnancy and risk of pre-eclampsia: a Swedish register-based study.
Bergman, Karl; Svanvik, Teresia; Basic, Carmen; Rosengren, Annika; Zverkova Sandström, Tatiana; Celind, Jimmy; Sjöland, Helen; Wikström, Anna-Karin; Schaufelberger, Maria; Thunström, Erik.
Afiliación
  • Bergman K; Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden karl.bergman@gu.se.
  • Svanvik T; Division of Cardiology, Tygerberg Hospital, Stellenbosch University, Faculty of Medicine and Health Sciences, Cape Town, Western Cape, South Africa.
  • Basic C; Department of Obstetrics and Gynecology, University of Gothenburg Institute of Clinical Sciences, Göteborg, Sweden.
  • Rosengren A; Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Zverkova Sandström T; Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Celind J; Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Sjöland H; Department of Pediatrics, University of Gothenburg Institute of Clinical Sciences, Göteborg, Sweden.
  • Wikström AK; Sahlgrenska Osteoporosis Centre, University of Gothenburg Institute of Medicine, Göteborg, Sweden.
  • Schaufelberger M; Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Thunström E; Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Open Heart ; 11(1)2024 May 23.
Article en En | MEDLINE | ID: mdl-38782544
ABSTRACT
BACKGROUND AND

AIMS:

Pre-eclampsia complicates 3-5% of pregnancies worldwide and is associated with adverse outcomes for the mother and the offspring. Pre-eclampsia and heart failure have common risk factors, including hypertension, obesity and diabetes. It is not known whether heart failure increases the risk of pre-eclampsia. This study examines whether pregestational heart failure increases the risk of pre-eclampsia.

METHODS:

In a registry-based case-cohort study that included all pregnancies in Sweden (n=3 125 527) between 1990 and 2019, all pregnancies with pre-eclampsia (n=90 354) were identified and up to five control pregnancies (n=451 466) for each case were chosen, matched on the mother's birth year. Multiple logistic regression analysis was used to evaluate the impact of heart failure on the risk of pre-eclampsia, with adjustment for established risk factors and other cardiovascular diseases.

RESULTS:

Women with heart failure had no increased risk for pre-eclampsia, OR 1.02 (95% CI 0.69 to 1.50). Women with valvular heart disease had an increased OR of preterm pre-eclampsia, with an adjusted OR of 1.78 (95% CI 1.04 to 3.06). Hypertension and diabetes were independent risk factors for pre-eclampsia. Obesity, multifetal pregnancies, in vitro fertilisation, older age, Nordic origin and nulliparity were more common among women who developed pre-eclampsia compared with controls.

CONCLUSION:

Women with heart failure do not have an increased risk of pre-eclampsia. However, women with valvular heart disease prior to pregnancy have an increased risk of developing preterm pre-eclampsia independent of other known risk factors.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Preeclampsia / Sistema de Registros Límite: Adult / Female / Humans / Pregnancy País/Región como asunto: Europa Idioma: En Revista: Open Heart Año: 2024 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Preeclampsia / Sistema de Registros Límite: Adult / Female / Humans / Pregnancy País/Región como asunto: Europa Idioma: En Revista: Open Heart Año: 2024 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Reino Unido