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Active metabolomics identify potential functional metabolites for preeclampsia prevention.
Zhang, Zhongxiao; He, Ping; Chen, Danni; Tan, Yan; Chen, Ailan; Bian, Zheng; Chen, Tingting.
Afiliación
  • Zhang Z; Department of Gynaecology and Obstetrics, Tongren Hospital, Shanghai Jiaotong University School of Medicine, 1111XianXia Road, Shanghai 200336, China; Hongqiao International Institute of Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • He P; Department of Gynaecology and Obstetrics, Tongren Hospital, Shanghai Jiaotong University School of Medicine, 1111XianXia Road, Shanghai 200336, China.
  • Chen D; Department of Gynaecology and Obstetrics, Tongren Hospital, Shanghai Jiaotong University School of Medicine, 1111XianXia Road, Shanghai 200336, China.
  • Tan Y; Department of Gynaecology and Obstetrics, Tongren Hospital, Shanghai Jiaotong University School of Medicine, 1111XianXia Road, Shanghai 200336, China.
  • Chen A; Department of Gynaecology and Obstetrics, Tongren Hospital, Shanghai Jiaotong University School of Medicine, 1111XianXia Road, Shanghai 200336, China.
  • Bian Z; Department of Gynaecology and Obstetrics, Tongren Hospital, Shanghai Jiaotong University School of Medicine, 1111XianXia Road, Shanghai 200336, China. Electronic address: BZ4587@shtrhospital.com.
  • Chen T; Department of Gynaecology and Obstetrics, Tongren Hospital, Shanghai Jiaotong University School of Medicine, 1111XianXia Road, Shanghai 200336, China. Electronic address: ctt2141@shtrhospital.com.
Clin Chim Acta ; 560: 119717, 2024 Jun 15.
Article en En | MEDLINE | ID: mdl-38782157
ABSTRACT

BACKGROUND:

Preeclampsia (PE) is a leading cause of maternal and fetal morbidity and mortality, with limited effective clinical treatment options. Active metabolomics offers a promising approach to uncover metabolic changes in PE and identify potential biomarkers or therapeutic targets. This study performed untargeted metabolomics using LC-MS to compare serum samples from preeclampsia and normal pregnancies.

METHODS:

We performed untargeted metabolomics using liquid chromatography-mass spectrometry (LC-MS) to compare serum samples from PE patients and normal pregnancies. We analyzed the alterations in metabolites and conducted functional experiments to assess the effects of LysoPE(160) on trophoblast cell invasion and migration. Mechanistic studies were performed to explore the potential targeting of GSK-3ß by LysoPE(160).

RESULTS:

Our metabolomics analysis revealed significant alterations in several metabolites, including lysophosphatidylcholines and organic acids. Notably, LysoPE(160) was found to be downregulated in the serum of PE patients. Functional experiments demonstrated that LysoPE(160) could promote trophoblast cell invasion and migration. Mechanistic studies suggest that the protective effect of LysoPE(160) against PE might be mediated through the modulation of the GSK-3ß/ß-Catenin pathway, with LysoPE(160) potentially targeting the GSK-3ß protein.

CONCLUSIONS:

Our findings highlight the potential role of LysoPE(160) in the pathophysiology of PE and its ability to modulate the GSK-3ß/ß-Catenin pathway. These results provide new insights into the metabolic changes associated with PE and suggest that LysoPE(160) could serve as a promising biomarker or therapeutic target for the prevention and treatment of PE.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Preeclampsia / Metabolómica / Glucógeno Sintasa Quinasa 3 beta Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Clin Chim Acta Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Preeclampsia / Metabolómica / Glucógeno Sintasa Quinasa 3 beta Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Clin Chim Acta Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos