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Trace element status in canine endocrine diseases.
Larrán, Belén; Loste, Araceli; Borobia, Marta; Miranda, Marta; López-Alonso, Marta; Herrero-Latorre, Carlos; Marca, M Carmen; Orjales, Inmaculada.
Afiliación
  • Larrán B; Departamento de Patoloxía animal, Facultade de Veterinaria, Campus Terra, Universidade de Santiago de Compostela, 27002 Lugo, Spain; Hospital Veterinario Universitario Rof Codina, Facultade de Veterinaria, Campus Terra, Universidade de Santiago de Compostela, 27002 Lugo, Spain.
  • Loste A; Departamento de Patología Animal, Facultad de Veterinaria, Universidad de Zaragoza, 50013 Zaragoza, Spain; Servicio de Endocrinología, Hospital Veterinario de la Universidad de Zaragoza, 50013 Zaragoza, Spain; Instituto Agroalimentario de Aragón-IA2-, Universidad de Zaragoza, 50013 Zaragoza, Spain.
  • Borobia M; Departamento de Patología Animal, Facultad de Veterinaria, Universidad de Zaragoza, 50013 Zaragoza, Spain; Servicio de Endocrinología, Hospital Veterinario de la Universidad de Zaragoza, 50013 Zaragoza, Spain.
  • Miranda M; Hospital Veterinario Universitario Rof Codina, Facultade de Veterinaria, Campus Terra, Universidade de Santiago de Compostela, 27002 Lugo, Spain; Departamento de Anatomía, Producción Animal e Ciencias Clínicas Veterinarias, Facultade de Veterinaria, Campus Terra, Universidade de Santiago de Composte
  • López-Alonso M; Departamento de Patoloxía animal, Facultade de Veterinaria, Campus Terra, Universidade de Santiago de Compostela, 27002 Lugo, Spain.
  • Herrero-Latorre C; Instituto de Investigación en Análises Químicas e Biolóxicas, Departamento de Química Analítica, Nutrición e Bromatoloxía, Facultade de Ciencias, Campus Terra, Universidade de Santiago de Compostela, 27002 Lugo, Spain.
  • Marca MC; Departamento de Patología Animal, Facultad de Veterinaria, Universidad de Zaragoza, 50013 Zaragoza, Spain; Servicio de Endocrinología, Hospital Veterinario de la Universidad de Zaragoza, 50013 Zaragoza, Spain.
  • Orjales I; Hospital Veterinario Universitario Rof Codina, Facultade de Veterinaria, Campus Terra, Universidade de Santiago de Compostela, 27002 Lugo, Spain; Departamento de Anatomía, Producción Animal e Ciencias Clínicas Veterinarias, Facultade de Veterinaria, Campus Terra, Universidade de Santiago de Composte
Res Vet Sci ; 174: 105309, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38781816
ABSTRACT
A balanced trace element status is essential for the optimal functioning of all organisms. However, their concentrations are often altered in diverse medical conditions. This study investigated the trace element profiles in plasma samples of dogs with endocrine diseases and used chemometric techniques to explore their associations with biochemical data. Thirteen elements (As, Cd, Co, Cr, Cu, Fe, Hg, Mn, Mo, Ni, Pb, Se and Zn) were measured in 40 dogs with hyperadrenocorticism (HAC), 29 dogs with diabetes mellitus (DM), 11 dogs with hypothyroidism (HT) and 30 control dogs using inductively coupled plasma mass spectrometry (ICP-MS). Statistically significant differences were observed for As, Cu, Mo, Se and Zn. In comparison with the control group, the HT patients had higher As and lower Se levels, while the HAC group had higher concentrations of Mo. All three disease groups had higher Cu and Zn concentrations than the control group, with the DM group having higher Cu concentrations and the HAC group higher Zn concentrations than the other endocrinopathy groups. The chemometric analysis revealed distinctive association patterns for discriminating each pathology group and the control group. Moreover, the analysis revealed the following associations Mo with glucose levels and Cu with fructosamine levels in the DM group, As with cortisol levels in the HAC group, and Se with TT4 levels and As with TSH levels in the HT group. The study findings provide valuable insights into the complex relationships between trace elements and endocrinopathies, elucidating the associations with biochemical markers in these diseases. Larger-scale studies are necessary to fully understand the observed relationships and explore the potential clinical applications.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligoelementos / Enfermedades de los Perros / Enfermedades del Sistema Endocrino Límite: Animals Idioma: En Revista: Res Vet Sci Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligoelementos / Enfermedades de los Perros / Enfermedades del Sistema Endocrino Límite: Animals Idioma: En Revista: Res Vet Sci Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido