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Durable radiologic and molecular complete response following nivolumab in an HNSCC patient with UV signature and HIV.
Adibi, Ashkan; Tokat, Ünal Metin; Özgü, Eylül; Mamyrov, Nurseit; Aydin, Esranur; Bilgiç, Sevval Nur; Tutar, Onur; Demiray, Mutlu.
Afiliación
  • Adibi A; Medicana Health Group, Precision Oncology Center, Istanbul, Turkiye; Istanbul University, Institute of Oncology, Department of Basic Oncology, Division of Cancer Genetics, Istanbul, Turkiye.
  • Tokat ÜM; Medicana Health Group, Precision Oncology Center, Istanbul, Turkiye.
  • Özgü E; Medicana Health Group, Precision Oncology Center, Istanbul, Turkiye.
  • Mamyrov N; Medicana Health Group, Precision Oncology Center, Istanbul, Turkiye.
  • Aydin E; Medicana Health Group, Precision Oncology Center, Istanbul, Turkiye.
  • Bilgiç SN; Medicana Health Group, Precision Oncology Center, Istanbul, Turkiye.
  • Tutar O; Istanbul University, Cerrahpasa Faculty of Medicine, Department of Internal Medicine, Istanbul, Turkiye.
  • Demiray M; Medicana Health Group, Precision Oncology Center, Istanbul, Turkiye. Electronic address: drdemiray@gmail.com.
Oral Oncol ; 154: 106859, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38781626
ABSTRACT
Cancer patients living with HIV (CPLWH) may experience increased mortality risk. Furthermore, they have been historically excluded from clinical trials due to safety concerns. Our patient with squamous cell carcinoma of the lower lip received radiotherapy and platinum-based chemotherapy but declined by multiple centers due to his accidental HIV status. Genomic profiling revealed CDKN2A/B, PBRM1, TP53, and TERT alterations corresponding to UV signature, and high tumor mutational burden with positive PD-L1 staining. Accordingly, we report a durable radiologic and molecular complete response upon nivolumab plus IVC and antiretroviral therapy (ART). We demonstrated the safety and efficacy of ICIs, and feasibility of managing adverse events caused by antitumor, antiviral, and integrative therapies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / Carcinoma de Células Escamosas de Cabeza y Cuello / Nivolumab Límite: Humans / Male / Middle aged Idioma: En Revista: Oral Oncol Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / Carcinoma de Células Escamosas de Cabeza y Cuello / Nivolumab Límite: Humans / Male / Middle aged Idioma: En Revista: Oral Oncol Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido