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Patterns of Progression of Nonproliferative Diabetic Retinopathy Using Non-Invasive Imaging.
Marques, Inês Pereira; Ribeiro, Maria Luísa; Santos, Torcato; Reste-Ferreira, Débora; Mendes, Luís; Martinho, António Cunha-Vaz; Santos, Ana Rita; Figueira, João; Lobo, Conceição; Cunha-Vaz, José.
Afiliación
  • Marques IP; AIBILI - Association for Innovation and Biomedical Research on Light and Image (AIBILI), Coimbra, Portugal.
  • Ribeiro ML; Coimbra Ophthalmology Reading Centre (CORC), Coimbra, Portugal.
  • Santos T; Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
  • Reste-Ferreira D; Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal.
  • Mendes L; AIBILI - Association for Innovation and Biomedical Research on Light and Image (AIBILI), Coimbra, Portugal.
  • Martinho AC; Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
  • Santos AR; Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal.
  • Figueira J; AIBILI - Association for Innovation and Biomedical Research on Light and Image (AIBILI), Coimbra, Portugal.
  • Lobo C; AIBILI - Association for Innovation and Biomedical Research on Light and Image (AIBILI), Coimbra, Portugal.
  • Cunha-Vaz J; AIBILI - Association for Innovation and Biomedical Research on Light and Image (AIBILI), Coimbra, Portugal.
Transl Vis Sci Technol ; 13(5): 22, 2024 May 01.
Article en En | MEDLINE | ID: mdl-38780953
ABSTRACT

Purpose:

To identify progression of nonproliferative diabetic retinopathy (NPDR) in patients with type 2 diabetes by combining optical coherence tomography angiography (OCTA) metrics and color fundus photography (CFP) images.

Methods:

This study was a post hoc analysis of a prospective longitudinal cohort study (CORDIS, NCT03696810) with 2-year duration. This study enrolled 122 eyes. Ophthalmological examinations included OCTA and CFP. OCTA metrics included skeletonized vessel density (SVD) and perfusion density (PD) at the superficial capillary plexus (SCP) and deep capillary plexus (DCP). Microaneurysm turnover analysis and Early Treatment Diabetic Retinopathy Study (ETDRS) grading for diabetic retinopathy (DR) severity assessment were performed on 7-field CFP.

Results:

Eyes graded as ETDRS level 20 showed significant capillary nonperfusion predominantly in the inner ring area in the SCP (P < 0.001), whereas eyes graded as ETDRS level 35 and ETDRS levels 43 and 47 showed significant capillary nonperfusion in both the SCP and DCP in both inner and outer rings (P < 0.001). When evaluating rates of progression in capillary nonperfusion for the 2-year period of follow-up, changes were found predominantly in the DCP for SVD and PD and were better identified in the outer ring area. Microaneurysm turnover contributes to the characterization of NPDR progression by discriminating ETDRS level 35 from ETDRS levels 43 and 47 (P < 0.001), which could not be achieved using only OCTA metrics.

Conclusions:

Patterns of progression of NPDR can be identified combining OCTA examinations of the superficial and deep retinal capillary plexi of central retina and determination of microaneurysm turnover from fundus photographs. Translational Relevance Our study reports results from a registered clinical trial that advances understanding of disease progression in NPDR.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vasos Retinianos / Angiografía con Fluoresceína / Progresión de la Enfermedad / Tomografía de Coherencia Óptica / Retinopatía Diabética Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Transl Vis Sci Technol Año: 2024 Tipo del documento: Article País de afiliación: Portugal Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vasos Retinianos / Angiografía con Fluoresceína / Progresión de la Enfermedad / Tomografía de Coherencia Óptica / Retinopatía Diabética Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Transl Vis Sci Technol Año: 2024 Tipo del documento: Article País de afiliación: Portugal Pais de publicación: Estados Unidos