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Association of Urinary Biomarkers of Tobacco Exposure with Lung Cancer Risk in African American and White Cigarette Smokers in the Southern Community Cohort Study.
Murphy, Sharon E; Guillermo, Cherie; Thomson, Nicole M; Carmella, Steven G; Wittmann, Milo; Aldrich, Melinda C; Cai, Qiuyin; Sullivan, Shannon M; Stram, Daniel O; Le Marchand, Loïc; Hecht, Stephen S; Blot, William J; Park, S Lani.
Afiliación
  • Murphy SE; Department of Biochemistry Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota.
  • Guillermo C; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
  • Thomson NM; Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
  • Carmella SG; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
  • Wittmann M; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
  • Aldrich MC; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
  • Cai Q; Division of Genetic Medicine, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.
  • Sullivan SM; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.
  • Stram DO; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
  • Le Marchand L; Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California.
  • Hecht SS; Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
  • Blot WJ; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
  • Park SL; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.
Cancer Epidemiol Biomarkers Prev ; 33(8): 1073-1082, 2024 Aug 01.
Article en En | MEDLINE | ID: mdl-38780906
ABSTRACT

BACKGROUND:

After accounting for smoking history, lung cancer incidence is greater in African Americans than Whites. In the multiethnic cohort, total nicotine equivalents (TNE) are higher in African Americans than Whites at similar reported cigarettes per day. Greater toxicant uptake per cigarette may contribute to the greater lung cancer risk of African Americans.

METHODS:

In a nested case-control lung cancer study within the Southern Community Cohort, smoking-related biomarkers were measured in 259 cases and 503 controls (40% White; 56% African American). TNE, the trans-3-hydroxycotinine/cotinine ratio, 4-(methylnitrosamino)-1-3-(pyridyl)-1-butanol (NNAL), mercapturic acid metabolites of volatile organic compounds, phenanthrene metabolites, cadmium (Cd), and (Z)-7-(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopenyl]hept-5-enoic acid were quantified in urine. Unconditional logistic regression was used to estimate the ORs and 95% confidence intervals (CI) for each biomarker and lung cancer risk.

RESULTS:

TNE, NNAL, and Cd were higher in cases than controls (adjusted for age, race, sex, body mass index, and cigarettes per day). Among cases, these levels were higher in African Americans compared with Whites. After accounting for age, sex, body mass index, and pack-years, a one-SD increase in log-TNE (OR = 1.30; 95% CI, 1.10-1.54) and log-NNAL (OR = 1.27; 95% CI, 1.03-1.58 with TNE adjustment) was associated with lung cancer risk. In this study, in which NNAL concentration is relatively high, the association for log-TNE was attenuated after adjustment for log-NNAL.

CONCLUSIONS:

Smoking-related biomarkers provide additional information for lung cancer risk in smokers beyond smoking pack-years. IMPACT Urinary NNAL, TNE, and Cd concentrations in current smokers, particularly African American smokers, may be useful for predicting lung cancer risk.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Negro o Afroamericano / Población Blanca / Neoplasias Pulmonares Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Cancer Epidemiol Biomarkers Prev Asunto de la revista: BIOQUIMICA / EPIDEMIOLOGIA / NEOPLASIAS Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Negro o Afroamericano / Población Blanca / Neoplasias Pulmonares Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Cancer Epidemiol Biomarkers Prev Asunto de la revista: BIOQUIMICA / EPIDEMIOLOGIA / NEOPLASIAS Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos