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Sex Differences in Aging-related Myocardial Stiffening Quantitatively Measured with MR Elastography.
Arani, Arvin; Murphy, Matthew C; Bhopalwala, Huzefa; Arunachalam, Shivaram P; Rossman, Phillip J; Trzasko, Joshua D; Glaser, Kevin; Sui, Yi; Gunderson, Tina; Arruda-Olson, Adelaide M; Manduca, Armando; Kantarci, Kejal; Ehman, Richard L; Araoz, Philip A.
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  • Arani A; From the Departments of Radiology (A.A., M.C.M., H.B., S.P.A., P.J.R., J.D.T., K.G., Y.S., A.M., K.K., R.L.E., P.A.A.), Quantitative Health Science (T.G.), and Cardiology (A.M.A.O.), Mayo Clinic, 200 First St SW, Rochester, MN 55905.
  • Murphy MC; From the Departments of Radiology (A.A., M.C.M., H.B., S.P.A., P.J.R., J.D.T., K.G., Y.S., A.M., K.K., R.L.E., P.A.A.), Quantitative Health Science (T.G.), and Cardiology (A.M.A.O.), Mayo Clinic, 200 First St SW, Rochester, MN 55905.
  • Bhopalwala H; From the Departments of Radiology (A.A., M.C.M., H.B., S.P.A., P.J.R., J.D.T., K.G., Y.S., A.M., K.K., R.L.E., P.A.A.), Quantitative Health Science (T.G.), and Cardiology (A.M.A.O.), Mayo Clinic, 200 First St SW, Rochester, MN 55905.
  • Arunachalam SP; From the Departments of Radiology (A.A., M.C.M., H.B., S.P.A., P.J.R., J.D.T., K.G., Y.S., A.M., K.K., R.L.E., P.A.A.), Quantitative Health Science (T.G.), and Cardiology (A.M.A.O.), Mayo Clinic, 200 First St SW, Rochester, MN 55905.
  • Rossman PJ; From the Departments of Radiology (A.A., M.C.M., H.B., S.P.A., P.J.R., J.D.T., K.G., Y.S., A.M., K.K., R.L.E., P.A.A.), Quantitative Health Science (T.G.), and Cardiology (A.M.A.O.), Mayo Clinic, 200 First St SW, Rochester, MN 55905.
  • Trzasko JD; From the Departments of Radiology (A.A., M.C.M., H.B., S.P.A., P.J.R., J.D.T., K.G., Y.S., A.M., K.K., R.L.E., P.A.A.), Quantitative Health Science (T.G.), and Cardiology (A.M.A.O.), Mayo Clinic, 200 First St SW, Rochester, MN 55905.
  • Glaser K; From the Departments of Radiology (A.A., M.C.M., H.B., S.P.A., P.J.R., J.D.T., K.G., Y.S., A.M., K.K., R.L.E., P.A.A.), Quantitative Health Science (T.G.), and Cardiology (A.M.A.O.), Mayo Clinic, 200 First St SW, Rochester, MN 55905.
  • Sui Y; From the Departments of Radiology (A.A., M.C.M., H.B., S.P.A., P.J.R., J.D.T., K.G., Y.S., A.M., K.K., R.L.E., P.A.A.), Quantitative Health Science (T.G.), and Cardiology (A.M.A.O.), Mayo Clinic, 200 First St SW, Rochester, MN 55905.
  • Gunderson T; From the Departments of Radiology (A.A., M.C.M., H.B., S.P.A., P.J.R., J.D.T., K.G., Y.S., A.M., K.K., R.L.E., P.A.A.), Quantitative Health Science (T.G.), and Cardiology (A.M.A.O.), Mayo Clinic, 200 First St SW, Rochester, MN 55905.
  • Arruda-Olson AM; From the Departments of Radiology (A.A., M.C.M., H.B., S.P.A., P.J.R., J.D.T., K.G., Y.S., A.M., K.K., R.L.E., P.A.A.), Quantitative Health Science (T.G.), and Cardiology (A.M.A.O.), Mayo Clinic, 200 First St SW, Rochester, MN 55905.
  • Manduca A; From the Departments of Radiology (A.A., M.C.M., H.B., S.P.A., P.J.R., J.D.T., K.G., Y.S., A.M., K.K., R.L.E., P.A.A.), Quantitative Health Science (T.G.), and Cardiology (A.M.A.O.), Mayo Clinic, 200 First St SW, Rochester, MN 55905.
  • Kantarci K; From the Departments of Radiology (A.A., M.C.M., H.B., S.P.A., P.J.R., J.D.T., K.G., Y.S., A.M., K.K., R.L.E., P.A.A.), Quantitative Health Science (T.G.), and Cardiology (A.M.A.O.), Mayo Clinic, 200 First St SW, Rochester, MN 55905.
  • Ehman RL; From the Departments of Radiology (A.A., M.C.M., H.B., S.P.A., P.J.R., J.D.T., K.G., Y.S., A.M., K.K., R.L.E., P.A.A.), Quantitative Health Science (T.G.), and Cardiology (A.M.A.O.), Mayo Clinic, 200 First St SW, Rochester, MN 55905.
  • Araoz PA; From the Departments of Radiology (A.A., M.C.M., H.B., S.P.A., P.J.R., J.D.T., K.G., Y.S., A.M., K.K., R.L.E., P.A.A.), Quantitative Health Science (T.G.), and Cardiology (A.M.A.O.), Mayo Clinic, 200 First St SW, Rochester, MN 55905.
Radiol Cardiothorac Imaging ; 6(3): e230140, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38780427
ABSTRACT
Purpose To investigate the feasibility of using quantitative MR elastography (MRE) to characterize the influence of aging and sex on left ventricular (LV) shear stiffness. Materials and Methods In this prospective study, LV myocardial shear stiffness was measured in 109 healthy volunteers (age range 18-84 years; mean age, 40 years ± 18 [SD]; 57 women, 52 men) enrolled between November 2018 and September 2019, using a 5-minute MRE acquisition added to a clinical MRI protocol. Linear regression models were used to estimate the association of cardiac MRI and MRE characteristics with age and sex; models were also fit to assess potential age-sex interaction. Results Myocardial shear stiffness significantly increased with age in female (age slope = 0.03 kPa/year ± 0.01, P = .009) but not male (age slope = 0.008 kPa/year ± 0.009, P = .38) volunteers. LV ejection fraction (LVEF) increased significantly with age in female volunteers (0.23% ± 0.08 per year, P = .005). LV end-systolic volume (LVESV) decreased with age in female volunteers (-0.20 mL/m2 ± 0.07, P = .003). MRI parameters, including T1, strain, and LV mass, did not demonstrate this interaction (P > .05). Myocardial shear stiffness was not significantly correlated with LVEF, LV stroke volume, body mass index, or any MRI strain metrics (P > .05) but showed significant correlations with LV end-diastolic volume/body surface area (BSA) (slope = -3 kPa/mL/m2 ± 1, P = .004, r2 = 0.08) and LVESV/BSA (-1.6 kPa/mL/m2 ± 0.5, P = .003, r2 = 0.08). Conclusion This study demonstrates that female, but not male, individuals experience disproportionate LV stiffening with natural aging, and these changes can be noninvasively measured with MRE. Keywords Cardiac, Elastography, Biological Effects, Experimental Investigations, Sexual Dimorphisms, MR Elastography, Myocardial Shear Stiffness, Quantitative Stiffness Imaging, Aging Heart, Myocardial Biomechanics, Cardiac MRE Supplemental material is available for this article. Published under a CC BY 4.0 license.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento / Diagnóstico por Imagen de Elasticidad / Ventrículos Cardíacos Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Radiol Cardiothorac Imaging Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento / Diagnóstico por Imagen de Elasticidad / Ventrículos Cardíacos Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Radiol Cardiothorac Imaging Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos