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Surgical Protocol for Partial Heart Transplantation in Growing Piglets.
Medina, Cathlyn K; Aykut, Berk; Kang, Lillian; McVadon, Deani; Overbey, Douglas M; Helke, Kristi L; Taylor, Carolyn L; Fitzgerald, David C; Hassid, Marc; Braxton, Alicia M; Miller, Stephen G; Mealer, Corey; Ho, Chak-Sum; Whitworth, Kristin M; Prather, Randall S; Moya-Mendez, Mary E; Jeffs, Sydney; Parker, Lauren E; Turek, Joseph W; Rajab, Taufiek Konrad.
Afiliación
  • Medina CK; Department of Surgery, Duke University Medical Center, Durham, NC, USA.
  • Aykut B; Department of Surgery, Duke University Medical Center, Durham, NC, USA.
  • Kang L; Department of Surgery, Duke University Medical Center, Durham, NC, USA.
  • McVadon D; Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA.
  • Overbey DM; Department of Surgery, Duke University Medical Center, Durham, NC, USA.
  • Helke KL; Department of Comparative Medicine, Medical University of South Carolina, Charleston, SC, USA.
  • Taylor CL; Department of Comparative Medicine, Medical University of South Carolina, Charleston, SC, USA.
  • Fitzgerald DC; Division of Cardiovascular Perfusion, Department of Clinical Sciences, Medical University of South Carolina, Charleston, SC, USA.
  • Hassid M; Division of Pediatric Cardiac Anesthesia, Department of Anesthesia and Perioperative Medicine, Medical University of South Carolina, Charleston, SC, USA.
  • Braxton AM; Department of Comparative Medicine, Medical University of South Carolina, Charleston, SC, USA.
  • Miller SG; Department of Pediatrics, Duke University Medical Center, Durham, NC, USA.
  • Mealer C; Department of Comparative Medicine, Medical University of South Carolina, Charleston, SC, USA.
  • Ho CS; Gift of Hope Organ and Tissue Donor Network, Chicago, IL, USA.
  • Whitworth KM; National Swine Resource and Research Center, University of Missouri, MO, USA.
  • Prather RS; National Swine Resource and Research Center, University of Missouri, MO, USA.
  • Moya-Mendez ME; Department of Surgery, Duke University Medical Center, Durham, NC, USA.
  • Jeffs S; Department of Surgery, Duke University Medical Center, Durham, NC, USA.
  • Parker LE; Department of Surgery, Duke University Medical Center, Durham, NC, USA.
  • Turek JW; Department of Surgery, Duke University Medical Center, Durham, NC, USA.
  • Rajab TK; Department of Surgery, Arkansas Children's Hospital, Little Rock, AR, USA.
World J Pediatr Congenit Heart Surg ; : 21501351241245115, 2024 May 23.
Article en En | MEDLINE | ID: mdl-38780414
ABSTRACT
Partial heart transplantation is a new approach to deliver growing heart valve implants. Partial heart transplants differ from heart transplants because only the part of the heart containing the necessary heart valve is transplanted. This allows partial heart transplants to grow, similar to the valves in heart transplants. However, the transplant biology of partial heart transplantation remains unexplored. This is a critical barrier to progress of the field. Without knowledge about the specific transplant biology of partial heart transplantation, children with partial heart transplants are empirically treated like children with heart transplants because the valves in heart transplants are known to grow. In order to progress the field, an animal model for partial heart transplantation is necessary. Here, we contribute our surgical protocol for partial heart transplantation in growing piglets. All aspects of partial heart transplantation, including the donor procedure, the recipient procedure, and recipient perioperative care are described in detail. There are important nuances in the conduct of virtually all aspects of open heart surgery that differs in piglets from humans. Our surgical protocol, which is based on our experience with 34 piglets, will allow other investigators to leverage our experience to seek fundamental knowledge about the nature of partial heart transplants. This is significant because the partial heart transplant model in piglets is complex and very resource intensive.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: World J Pediatr Congenit Heart Surg Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: World J Pediatr Congenit Heart Surg Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos