Short-chain fatty acids: bridges between diet, gut microbiota, and health.

Wang, Ling-Yun; He, Li-Hong; Xu, Li-Jun; Li, Shi-Bo

Wang, Ling-Yun; He, Li-Hong; Xu, Li-Jun; Li, Shi-Bo.

Afiliación

Wang LY; Department of Infectious Diseases, Zhoushan Hospital, Zhejiang University, Zhoushan, China.
He LH; College of Medicine, Zhejiang University, Hangzhou, China.
Xu LJ; College of Medicine, Zhejiang University, Hangzhou, China.
Li SB; Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

J Gastroenterol Hepatol ; 2024 May 23.

Article en En | MEDLINE | ID: mdl-38780349

ABSTRACT

ABSTRACT

In recent years, gut microbiota has become a hot topic in the fields of medicine and life sciences. Short-chain fatty acids (SCFAs), the main metabolites of gut microbiota produced by microbial fermentation of dietary fiber, play a vital role in healthy and ill hosts. SCFAs regulate the process of metabolism, immune, and inflammation and have therapeutic effects on gastrointestinal and neurological disorders, as well as antitumor properties. This review summarized the production, distribution, and molecular mechanism of SCFAs, as well as their mechanisms of action in healthy and ill hosts. In addition, we also emphasized the negative effects of SCFAs, aiming to provide the public with a more comprehensive understanding of SCFAs.

Palabras clave

SCFAs; gut microbiota; immune; inflammation; metabolism

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Gastroenterol Hepatol Asunto de la revista: GASTROENTEROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Australia

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