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Restoring adiponectin via rosiglitazone ameliorates tissue wasting in mice with lung cancer.
Langer, Henning Tim; Ramsamooj, Shakti; Dantas, Ezequiel; Murthy, Anirudh; Ahmed, Mujmmail; Ahmed, Tanvir; Hwang, Seo-Kyoung; Grover, Rahul; Pozovskiy, Rita; Liang, Roger J; Queiroz, Andre Lima; Brown, Justin C; White, Eileen P; Janowitz, Tobias; Goncalves, Marcus D.
Afiliación
  • Langer HT; Division of Endocrinology, Weill Department of Medicine, Weill Cornell Medicine, New York, New York, USA.
  • Ramsamooj S; Meyer Cancer Center, Weill Cornell Medicine, New York, New York, USA.
  • Dantas E; Division of Endocrinology, Weill Department of Medicine, Weill Cornell Medicine, New York, New York, USA.
  • Murthy A; Meyer Cancer Center, Weill Cornell Medicine, New York, New York, USA.
  • Ahmed M; Division of Endocrinology, Weill Department of Medicine, Weill Cornell Medicine, New York, New York, USA.
  • Ahmed T; Meyer Cancer Center, Weill Cornell Medicine, New York, New York, USA.
  • Hwang SK; Division of Endocrinology, Weill Department of Medicine, Weill Cornell Medicine, New York, New York, USA.
  • Grover R; Meyer Cancer Center, Weill Cornell Medicine, New York, New York, USA.
  • Pozovskiy R; Division of Endocrinology, Weill Department of Medicine, Weill Cornell Medicine, New York, New York, USA.
  • Liang RJ; Meyer Cancer Center, Weill Cornell Medicine, New York, New York, USA.
  • Queiroz AL; Division of Endocrinology, Weill Department of Medicine, Weill Cornell Medicine, New York, New York, USA.
  • Brown JC; Meyer Cancer Center, Weill Cornell Medicine, New York, New York, USA.
  • White EP; Division of Endocrinology, Weill Department of Medicine, Weill Cornell Medicine, New York, New York, USA.
  • Janowitz T; Meyer Cancer Center, Weill Cornell Medicine, New York, New York, USA.
  • Goncalves MD; Weill Cornell Medical College, Weill Cornell Medicine, New York, New York, USA.
Acta Physiol (Oxf) ; 240(8): e14167, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38779820
ABSTRACT

AIM:

To investigate systemic regulators of the cancer-associated cachexia syndrome (CACS) in a pre-clinical model for lung cancer with the goal to identify therapeutic targets for tissue wasting.

METHODS:

Using the Kras/Lkb1 (KL) mouse model, we found that CACS is associated with white adipose tissue (WAT) dysfunction that directly affects skeletal muscle homeostasis. WAT transcriptomes showed evidence of reduced adipogenesis, and, in agreement, we found low levels of circulating adiponectin. To preserve adipogenesis and restore adiponectin levels, we treated mice with the PPAR-γ agonist, rosiglitazone.

RESULTS:

Rosiglitazone treatment increased serum adiponectin levels, delayed weight loss, and preserved skeletal muscle and adipose tissue mass, as compared to vehicle-treated mice. The preservation of muscle mass with rosiglitazone was associated with increases in AMPK and AKT activity. Similarly, activation of the adiponectin receptors in muscle cells increased AMPK activity, anabolic signaling, and protein synthesis.

CONCLUSION:

Our data suggest that PPAR-γ agonists may be a useful adjuvant therapy to preserve tissue mass in lung cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Caquexia / Adiponectina / Rosiglitazona / Neoplasias Pulmonares Límite: Animals Idioma: En Revista: Acta Physiol (Oxf) Asunto de la revista: FISIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Caquexia / Adiponectina / Rosiglitazona / Neoplasias Pulmonares Límite: Animals Idioma: En Revista: Acta Physiol (Oxf) Asunto de la revista: FISIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido