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The Therapeutic Effects of Baicalein on the Hepatopulmonary Syndrome in the Rat Model of Chronic Common Bile Duct Ligation.
Zeng, Ziyang; Lei, Yuhao; Yang, Chunyong; Wu, Xianfeng; Zhang, Liang; Yang, Zhiyong; Chen, Lin; Wang, Xiaobo; Belguise, Karine; Li, Yujie; Yi, Bin.
Afiliación
  • Zeng Z; Department of Anesthesiology, Southwest Hospital, Third Military Medical University, Chongqing, China.
  • Lei Y; Department of Anesthesiology, Southwest Hospital, Third Military Medical University, Chongqing, China.
  • Yang C; Department of Anesthesiology, Southwest Hospital, Third Military Medical University, Chongqing, China.
  • Wu X; Department of Anesthesiology, Southwest Hospital, Third Military Medical University, Chongqing, China.
  • Zhang L; Department of Anesthesiology, Chongqing Traditional Chinese Medicine Hospital, Chongqing, China.
  • Yang Z; Department of Anesthesiology, Southwest Hospital, Third Military Medical University, Chongqing, China.
  • Chen L; Department of Anesthesiology, Southwest Hospital, Third Military Medical University, Chongqing, China.
  • Wang X; MCD, Center de Biologie Intégrative, Université de Toulouse, CNRS, UPS, Toulouse, France.
  • Belguise K; MCD, Center de Biologie Intégrative, Université de Toulouse, CNRS, UPS, Toulouse, France.
  • Li Y; Department of Anesthesiology, Southwest Hospital, Third Military Medical University, Chongqing, China.
  • Yi B; Department of Anesthesiology, Southwest Hospital, Third Military Medical University, Chongqing, China.
J Clin Transl Hepatol ; 12(5): 496-504, 2024 May 28.
Article en En | MEDLINE | ID: mdl-38779522
ABSTRACT
Background and

Aims:

Hepatopulmonary syndrome (HPS) is characterized by arterial oxygenation defects due to pulmonary vascular dilation in liver disease. To date, liver transplantation remains the only effective treatment for HPS. This study aimed to explore the preventative role of baicalein in HPS development.

Methods:

Sixty male rats were randomly assigned to three groups sham, common bile duct ligation (CBDL), and baicalein, receiving intraperitoneal injections of baicalein (40 mg·kg-1·d-1, diluted in saline) for 21 days. Survival rate, liver and kidney function, and bile acid metabolism levels were evaluated. Liver and lung angiogenesis and hepatic glycogen staining were assessed, and the expression of relevant proteins was evaluated by immunohistochemistry.

Results:

Baicalein improved survival rates and hypoxemia in rats post-CBDL, reducing angiogenic protein levels and enhancing glucose homeostasis. Compared to the untreated group, baicalein suppressed the expression of vascular endothelial growth factor, placental growth factors, matrix metalloprotease 9 and C-X-C motif chemokine 2, and it increased the expression of glycemic regulatory proteins, including dipeptidyl peptidase-4, sirtuin 1, peroxisome proliferator-activated receptor gamma co-activator 1α, and 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3.

Conclusion:

Baicalein significantly improves hepatic function and hypoxia in HPS rats by attenuating pathological angiogenesis in the liver and lungs, showing promise as a treatment for HPS.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Transl Hepatol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Transl Hepatol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos